The Role(s) of Eicosanoids and Exosomes in Human Parturition
The roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of...
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doaj-101a1275536648fe8a2243c1c8bcae542020-12-23T10:35:33ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-12-011110.3389/fphys.2020.594313594313The Role(s) of Eicosanoids and Exosomes in Human ParturitionEman Mosaad0Hassendrini N. Peiris1Olivia Holland2Olivia Holland3Isabella Morean Garcia4Murray D. Mitchell5School of Biomedical Science, Institute of Health and Biomedical Innovation – Centre for Children’s Health Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Science, Institute of Health and Biomedical Innovation – Centre for Children’s Health Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Science, Institute of Health and Biomedical Innovation – Centre for Children’s Health Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Medical Science, Griffith University, Southport, QLD, AustraliaSchool of Biomedical Science, Institute of Health and Biomedical Innovation – Centre for Children’s Health Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Science, Institute of Health and Biomedical Innovation – Centre for Children’s Health Research, Faculty of Health, Queensland University of Technology, Brisbane, QLD, AustraliaThe roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of a panel of those end products has exciting potential as diagnostics and prognostics of preterm labor and delivery. Exosomes and their contents represent an exciting new area for research of movement of key biological factors circulating between tissues and organs akin to a parallel endocrine system but involving key intracellular mediators. Eicosanoids and enzymes regulating their biosynthesis and metabolism as well as regulatory microRNAs have been identified within exosomes. In this review, the regulation of eicosanoid production, abundance and actions during pregnancy will be explored. Additionally, the functional significance of placental exosomes will be discussed.https://www.frontiersin.org/articles/10.3389/fphys.2020.594313/fullexosomeseicosanoidsprostaglandinspregnancyparturitiongestation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eman Mosaad Hassendrini N. Peiris Olivia Holland Olivia Holland Isabella Morean Garcia Murray D. Mitchell |
spellingShingle |
Eman Mosaad Hassendrini N. Peiris Olivia Holland Olivia Holland Isabella Morean Garcia Murray D. Mitchell The Role(s) of Eicosanoids and Exosomes in Human Parturition Frontiers in Physiology exosomes eicosanoids prostaglandins pregnancy parturition gestation |
author_facet |
Eman Mosaad Hassendrini N. Peiris Olivia Holland Olivia Holland Isabella Morean Garcia Murray D. Mitchell |
author_sort |
Eman Mosaad |
title |
The Role(s) of Eicosanoids and Exosomes in Human Parturition |
title_short |
The Role(s) of Eicosanoids and Exosomes in Human Parturition |
title_full |
The Role(s) of Eicosanoids and Exosomes in Human Parturition |
title_fullStr |
The Role(s) of Eicosanoids and Exosomes in Human Parturition |
title_full_unstemmed |
The Role(s) of Eicosanoids and Exosomes in Human Parturition |
title_sort |
role(s) of eicosanoids and exosomes in human parturition |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-12-01 |
description |
The roles that eicosanoids play during pregnancy and parturition are crucial to a successful outcome. A better understanding of the regulation of eicosanoid production and the roles played by the various end products during pregnancy and parturition has led to our view that accurate measurements of a panel of those end products has exciting potential as diagnostics and prognostics of preterm labor and delivery. Exosomes and their contents represent an exciting new area for research of movement of key biological factors circulating between tissues and organs akin to a parallel endocrine system but involving key intracellular mediators. Eicosanoids and enzymes regulating their biosynthesis and metabolism as well as regulatory microRNAs have been identified within exosomes. In this review, the regulation of eicosanoid production, abundance and actions during pregnancy will be explored. Additionally, the functional significance of placental exosomes will be discussed. |
topic |
exosomes eicosanoids prostaglandins pregnancy parturition gestation |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2020.594313/full |
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