Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya
Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort stud...
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doaj-10225a1c4d424a50bcff817b121418702020-11-24T21:10:47ZengMDPI AGNutrients2072-66432016-12-0181279410.3390/nu8120794nu8120794Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western KenyaEunice N. Toko0Odada P. Sumba1Ibrahim I. Daud2Sidney Ogolla3Maxwel Majiwa4Jesse T. Krisher5Collins Ouma6Arlene E. Dent7Rosemary Rochford8Saurabh Mehta9School of Biological and Physical Sciences, Maseno University, Kisumu, KenyaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, KenyaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, KenyaSchool of Biological and Physical Sciences, Maseno University, Kisumu, KenyaCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, KenyaDivision of Nutritional Sciences, Cornell University, 314 Savage Hall, Ithaca, NY 14853, USASchool of Biological and Physical Sciences, Maseno University, Kisumu, KenyaCase Western Reserve University, Cleveland, OH 44106, USASUNY Upstate Medical University, Syracuse, NY 13210, USADivision of Nutritional Sciences, Cornell University, 314 Savage Hall, Ithaca, NY 14853, USAMaternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes. Fifty-one percent of the women had insufficient (<75 nmol/L) and 21% had deficient (<50 nmol/L) plasma 25(OH)D concentration at enrollment. At birth, 74.4% of the infants had insufficient and 30% had deficient plasma 25(OH)D concentrations, measured in cord blood. Multivariate analysis controlling for maternal age and body mass index (BMI) at enrollment and gestational age at delivery found that deficient plasma 25(OH)D levels were associated with a four-fold higher risk of stunting in neonates (p = 0.04). These findings add to the existing literature about vitamin D and its association with linear growth in resource-limited settings, though randomized clinical trials are needed to establish causation.http://www.mdpi.com/2072-6643/8/12/794maternal vitamin D statuspregnancy outcomesstuntingAfricamalaria and helminth infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eunice N. Toko Odada P. Sumba Ibrahim I. Daud Sidney Ogolla Maxwel Majiwa Jesse T. Krisher Collins Ouma Arlene E. Dent Rosemary Rochford Saurabh Mehta |
spellingShingle |
Eunice N. Toko Odada P. Sumba Ibrahim I. Daud Sidney Ogolla Maxwel Majiwa Jesse T. Krisher Collins Ouma Arlene E. Dent Rosemary Rochford Saurabh Mehta Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya Nutrients maternal vitamin D status pregnancy outcomes stunting Africa malaria and helminth infections |
author_facet |
Eunice N. Toko Odada P. Sumba Ibrahim I. Daud Sidney Ogolla Maxwel Majiwa Jesse T. Krisher Collins Ouma Arlene E. Dent Rosemary Rochford Saurabh Mehta |
author_sort |
Eunice N. Toko |
title |
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya |
title_short |
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya |
title_full |
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya |
title_fullStr |
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya |
title_full_unstemmed |
Maternal Vitamin D Status and Adverse Birth Outcomes in Children from Rural Western Kenya |
title_sort |
maternal vitamin d status and adverse birth outcomes in children from rural western kenya |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2016-12-01 |
description |
Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes. Fifty-one percent of the women had insufficient (<75 nmol/L) and 21% had deficient (<50 nmol/L) plasma 25(OH)D concentration at enrollment. At birth, 74.4% of the infants had insufficient and 30% had deficient plasma 25(OH)D concentrations, measured in cord blood. Multivariate analysis controlling for maternal age and body mass index (BMI) at enrollment and gestational age at delivery found that deficient plasma 25(OH)D levels were associated with a four-fold higher risk of stunting in neonates (p = 0.04). These findings add to the existing literature about vitamin D and its association with linear growth in resource-limited settings, though randomized clinical trials are needed to establish causation. |
topic |
maternal vitamin D status pregnancy outcomes stunting Africa malaria and helminth infections |
url |
http://www.mdpi.com/2072-6643/8/12/794 |
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