Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect
Bacterial cell-cell communication or quorum sensing (QS) is a biological process commonly described as allowing bacteria belonging to a same pherotype to coordinate gene expression to cell density. In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors regulated by s...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-07-01
|
Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/6/8/2239 |
id |
doaj-102b1e88b0614955bd11dc9b50d59dc0 |
---|---|
record_format |
Article |
spelling |
doaj-102b1e88b0614955bd11dc9b50d59dc02020-11-24T21:38:04ZengMDPI AGToxins2072-66512014-07-01682239225510.3390/toxins6082239toxins6082239Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the InsectLeyla Slamti0Stéphane Perchat1Eugénie Huillet2Didier Lereclus3INRA, Unité MICALIS UMR-1319, La Minière, 78280 Guyancourt, FranceINRA, Unité MICALIS UMR-1319, La Minière, 78280 Guyancourt, FranceINRA, Unité MICALIS UMR-1319, La Minière, 78280 Guyancourt, FranceINRA, Unité MICALIS UMR-1319, La Minière, 78280 Guyancourt, FranceBacterial cell-cell communication or quorum sensing (QS) is a biological process commonly described as allowing bacteria belonging to a same pherotype to coordinate gene expression to cell density. In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors regulated by secreted and re-imported signaling peptides. The Bacillus quorum sensors Rap, NprR, and PlcR were previously identified as the first members of a new protein family called RNPP. Except for the Rap proteins, these RNPP regulators are transcription factors that directly regulate gene expression. QS regulates important biological functions in bacteria of the Bacillus cereus group. PlcR was first characterized as the main regulator of virulence in B. thuringiensis and B. cereus. More recently, the PlcR-like regulator PlcRa was characterized for its role in cysteine metabolism and in resistance to oxidative stress. The NprR regulator controls the necrotrophic properties allowing the bacteria to survive in the infected host. The Rap proteins negatively affect sporulation via their interaction with a phosphorelay protein involved in the activation of Spo0A, the master regulator of this differentiation pathway. In this review we aim at providing a complete picture of the QS systems that are sequentially activated during the lifecycle of B. cereus and B. thuringiensis in an insect model of infection.http://www.mdpi.com/2072-6651/6/8/2239RNPPcell-cell communicationBacillus thuringiensisadaptationvirulencenecrotrophismsporulationgene expression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leyla Slamti Stéphane Perchat Eugénie Huillet Didier Lereclus |
spellingShingle |
Leyla Slamti Stéphane Perchat Eugénie Huillet Didier Lereclus Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect Toxins RNPP cell-cell communication Bacillus thuringiensis adaptation virulence necrotrophism sporulation gene expression |
author_facet |
Leyla Slamti Stéphane Perchat Eugénie Huillet Didier Lereclus |
author_sort |
Leyla Slamti |
title |
Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect |
title_short |
Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect |
title_full |
Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect |
title_fullStr |
Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect |
title_full_unstemmed |
Quorum Sensing in Bacillus thuringiensis Is Required for Completion of a Full Infectious Cycle in the Insect |
title_sort |
quorum sensing in bacillus thuringiensis is required for completion of a full infectious cycle in the insect |
publisher |
MDPI AG |
series |
Toxins |
issn |
2072-6651 |
publishDate |
2014-07-01 |
description |
Bacterial cell-cell communication or quorum sensing (QS) is a biological process commonly described as allowing bacteria belonging to a same pherotype to coordinate gene expression to cell density. In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors regulated by secreted and re-imported signaling peptides. The Bacillus quorum sensors Rap, NprR, and PlcR were previously identified as the first members of a new protein family called RNPP. Except for the Rap proteins, these RNPP regulators are transcription factors that directly regulate gene expression. QS regulates important biological functions in bacteria of the Bacillus cereus group. PlcR was first characterized as the main regulator of virulence in B. thuringiensis and B. cereus. More recently, the PlcR-like regulator PlcRa was characterized for its role in cysteine metabolism and in resistance to oxidative stress. The NprR regulator controls the necrotrophic properties allowing the bacteria to survive in the infected host. The Rap proteins negatively affect sporulation via their interaction with a phosphorelay protein involved in the activation of Spo0A, the master regulator of this differentiation pathway. In this review we aim at providing a complete picture of the QS systems that are sequentially activated during the lifecycle of B. cereus and B. thuringiensis in an insect model of infection. |
topic |
RNPP cell-cell communication Bacillus thuringiensis adaptation virulence necrotrophism sporulation gene expression |
url |
http://www.mdpi.com/2072-6651/6/8/2239 |
work_keys_str_mv |
AT leylaslamti quorumsensinginbacillusthuringiensisisrequiredforcompletionofafullinfectiouscycleintheinsect AT stephaneperchat quorumsensinginbacillusthuringiensisisrequiredforcompletionofafullinfectiouscycleintheinsect AT eugeniehuillet quorumsensinginbacillusthuringiensisisrequiredforcompletionofafullinfectiouscycleintheinsect AT didierlereclus quorumsensinginbacillusthuringiensisisrequiredforcompletionofafullinfectiouscycleintheinsect |
_version_ |
1725935588488511488 |