Hepcidin: an important iron metabolism regulator in chronic kidney disease

• Main Authors: Sandra Azevedo Antunes, Maria Eugênia Fernandes Canziani
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Nefrologia
• Series: Brazilian Journal of Nephrology
• Subjects: anemia; chronic; inflammation; peptides; renal dialysis; renal insufficiency
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002016000300351&lng=en&tlng=en

Abstract Anemia is a common complication and its impact on morbimortality in patients with chronic kidney disease (CKD) is well known. The discovery of hepcidin and its functions has contributed to a better understanding of iron metabolism disorders in CKD anemia. Hepcidin is a peptide mainly produced by hepatocytes and, through a connection with ferroportin, it regulates iron absorption in the duodenum and its release of stock cells. High hepcidin concentrations described in patients with CKD, especially in more advanced stages are attributed to decreased renal excretion and increased production. The elevation of hepcidin has been associated with infection, inflammation, atherosclerosis, insulin resistance and oxidative stress. Some strategies were tested to reduce the effects of hepcidin in patients with CKD, however more studies are necessary to assess the impact of its modulation in the management of anemia in this population.