Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant?
BACKGROUND:There are animal data that indicate that prenatal environmental exposures have sex-specific effects on subsequent generations. In humans, an increase in birthweight has been reported if the maternal grandmother had smoked in the pregnancy giving rise to the mother. Here we assess whether...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3913581?pdf=render |
id |
doaj-103bbe20ec09444684114d2ff2821119 |
---|---|
record_format |
Article |
spelling |
doaj-103bbe20ec09444684114d2ff28211192020-11-25T01:33:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8678110.1371/journal.pone.0086781Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant?Laura L MillerMarcus PembreyGeorge Davey SmithKate NorthstoneJean GoldingBACKGROUND:There are animal data that indicate that prenatal environmental exposures have sex-specific effects on subsequent generations. In humans, an increase in birthweight has been reported if the maternal grandmother had smoked in the pregnancy giving rise to the mother. Here we assess whether prenatal exposure of either parent to cigarette smoke has a sex-specific effect on the grandchild's birth measurements. METHODS:Information from 12707 maternal and 9677 paternal grandmothers of children in the Avon Longitudinal Study of Parents and Children (ALSPAC) concerned whether they had smoked while expecting the study parent. Study children were weighed and measured at birth. Analyses to test effects of grandmaternal prenatal smoking used multiple regression allowing for several potential confounders; analyses were restricted to births to non-smoking study mothers. FINDINGS:After adjustment, the average birthweight, birth length and bmi measurements of the grandsons (but not granddaughters) were greater if the maternal grandmother smoked prenatally: birthweight = +61 [95% CI +30, +92] g; birth length = +0.19 [95% CI +0.02, +0.35] cm; BMI = +1.6 [95% CI +0.6, +2.6] g/m(2). Similar effects were seen in births to primiparae and multiparae. Additional allowance for maternal birthweight resulted in an average increase in boys to +100 g [95% CI +61, +140] g. There were no fetal growth differences if the paternal grandmother had smoked prenatally. CONCLUSIONS:The evidence from this study suggests that when the mother does not smoke in pregnancy the maternal grandmother's smoking habit in pregnancy has a positive association with her grandson's fetal growth.http://europepmc.org/articles/PMC3913581?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura L Miller Marcus Pembrey George Davey Smith Kate Northstone Jean Golding |
spellingShingle |
Laura L Miller Marcus Pembrey George Davey Smith Kate Northstone Jean Golding Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? PLoS ONE |
author_facet |
Laura L Miller Marcus Pembrey George Davey Smith Kate Northstone Jean Golding |
author_sort |
Laura L Miller |
title |
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
title_short |
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
title_full |
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
title_fullStr |
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
title_full_unstemmed |
Is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
title_sort |
is the growth of the fetus of a non-smoking mother influenced by the smoking of either grandmother while pregnant? |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND:There are animal data that indicate that prenatal environmental exposures have sex-specific effects on subsequent generations. In humans, an increase in birthweight has been reported if the maternal grandmother had smoked in the pregnancy giving rise to the mother. Here we assess whether prenatal exposure of either parent to cigarette smoke has a sex-specific effect on the grandchild's birth measurements. METHODS:Information from 12707 maternal and 9677 paternal grandmothers of children in the Avon Longitudinal Study of Parents and Children (ALSPAC) concerned whether they had smoked while expecting the study parent. Study children were weighed and measured at birth. Analyses to test effects of grandmaternal prenatal smoking used multiple regression allowing for several potential confounders; analyses were restricted to births to non-smoking study mothers. FINDINGS:After adjustment, the average birthweight, birth length and bmi measurements of the grandsons (but not granddaughters) were greater if the maternal grandmother smoked prenatally: birthweight = +61 [95% CI +30, +92] g; birth length = +0.19 [95% CI +0.02, +0.35] cm; BMI = +1.6 [95% CI +0.6, +2.6] g/m(2). Similar effects were seen in births to primiparae and multiparae. Additional allowance for maternal birthweight resulted in an average increase in boys to +100 g [95% CI +61, +140] g. There were no fetal growth differences if the paternal grandmother had smoked prenatally. CONCLUSIONS:The evidence from this study suggests that when the mother does not smoke in pregnancy the maternal grandmother's smoking habit in pregnancy has a positive association with her grandson's fetal growth. |
url |
http://europepmc.org/articles/PMC3913581?pdf=render |
work_keys_str_mv |
AT lauralmiller isthegrowthofthefetusofanonsmokingmotherinfluencedbythesmokingofeithergrandmotherwhilepregnant AT marcuspembrey isthegrowthofthefetusofanonsmokingmotherinfluencedbythesmokingofeithergrandmotherwhilepregnant AT georgedaveysmith isthegrowthofthefetusofanonsmokingmotherinfluencedbythesmokingofeithergrandmotherwhilepregnant AT katenorthstone isthegrowthofthefetusofanonsmokingmotherinfluencedbythesmokingofeithergrandmotherwhilepregnant AT jeangolding isthegrowthofthefetusofanonsmokingmotherinfluencedbythesmokingofeithergrandmotherwhilepregnant |
_version_ |
1725077887921422336 |