Moving forward with new data and approaches: a fresh look at anthracyclines in non-Hodgkin’s lymphoma

Anthracyclines have a central role in the management of non-Hodgkin’s lymphoma (NHL). The cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment regimen has been the standard of care for more than 20 years. Further improvements have been made to the efficacy of this chemotherapy...

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Bibliographic Details
Main Author: Dino Amadori
Format: Article
Language:English
Published: PAGEPress Publications 2011-10-01
Series:Hematology Reports
Subjects:
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/3868
Description
Summary:Anthracyclines have a central role in the management of non-Hodgkin’s lymphoma (NHL). The cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment regimen has been the standard of care for more than 20 years. Further improvements have been made to the efficacy of this chemotherapy by reducing the dosing interval and adding rituximab to the regimen. A major limitation to the use of anthracyclines is the development of cardiotoxicity as a late adverse event. Strategies to reduce cardiac events include changes to the dosing schedule for doxorubicin, use of the chelating agent dexrazoxane and the use of liposome-encapsulated doxorubicin. This latter strategy has demonstrated good efficacy and reduced cardiotoxicity in patients with NHL, including those at risk of developing cardiac effects.<br />
ISSN:2038-8322
2038-8330