Granulocytes: New Members of the Antigen-Presenting Cell Family
Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A subst...
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doaj-1046f0fe78624f06b5e16cb9a69a5ad72020-11-25T00:14:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-12-01810.3389/fimmu.2017.01781319852Granulocytes: New Members of the Antigen-Presenting Cell FamilyAng Lin0Ang Lin1Karin Loré2Karin Loré3Department of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet (KI), Solna, SwedenCenter for Molecular Medicine, Karolinska Institutet (KI), Stockholm, SwedenDepartment of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet (KI), Solna, SwedenCenter for Molecular Medicine, Karolinska Institutet (KI), Stockholm, SwedenGranulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of recent evidence demonstrates that granulocytes can acquire the function as antigen-presenting cells under pathological or inflammatory conditions. In addition, they can acquire surface expression of MHC class II and costimulatory molecules as well as T cell stimulatory behavior when cultured with selected cytokines. The classic view of granulocytes as terminally differentiated, short-lived phagocytes is therefore changing to phenotypically and functionally heterogeneous cells that are engaged in cross-talk with other leukocyte populations and provide an additional link between innate and adaptive immunity. In this brief review, we summarize the current knowledge on the antigen-presenting capacity of granulocyte subsets (neutrophils, eosinophils, and basophils). Underlying mechanisms, relevant physiological significance and potential controversies are also discussed.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01781/fullantigen presentationMHCneutrophileosinophilbasophil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ang Lin Ang Lin Karin Loré Karin Loré |
spellingShingle |
Ang Lin Ang Lin Karin Loré Karin Loré Granulocytes: New Members of the Antigen-Presenting Cell Family Frontiers in Immunology antigen presentation MHC neutrophil eosinophil basophil |
author_facet |
Ang Lin Ang Lin Karin Loré Karin Loré |
author_sort |
Ang Lin |
title |
Granulocytes: New Members of the Antigen-Presenting Cell Family |
title_short |
Granulocytes: New Members of the Antigen-Presenting Cell Family |
title_full |
Granulocytes: New Members of the Antigen-Presenting Cell Family |
title_fullStr |
Granulocytes: New Members of the Antigen-Presenting Cell Family |
title_full_unstemmed |
Granulocytes: New Members of the Antigen-Presenting Cell Family |
title_sort |
granulocytes: new members of the antigen-presenting cell family |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2017-12-01 |
description |
Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of recent evidence demonstrates that granulocytes can acquire the function as antigen-presenting cells under pathological or inflammatory conditions. In addition, they can acquire surface expression of MHC class II and costimulatory molecules as well as T cell stimulatory behavior when cultured with selected cytokines. The classic view of granulocytes as terminally differentiated, short-lived phagocytes is therefore changing to phenotypically and functionally heterogeneous cells that are engaged in cross-talk with other leukocyte populations and provide an additional link between innate and adaptive immunity. In this brief review, we summarize the current knowledge on the antigen-presenting capacity of granulocyte subsets (neutrophils, eosinophils, and basophils). Underlying mechanisms, relevant physiological significance and potential controversies are also discussed. |
topic |
antigen presentation MHC neutrophil eosinophil basophil |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01781/full |
work_keys_str_mv |
AT anglin granulocytesnewmembersoftheantigenpresentingcellfamily AT anglin granulocytesnewmembersoftheantigenpresentingcellfamily AT karinlore granulocytesnewmembersoftheantigenpresentingcellfamily AT karinlore granulocytesnewmembersoftheantigenpresentingcellfamily |
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