Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and...

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Main Authors: Ayşe Demirkan, Cornelia M van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P Pramstaller, Gerhard Liebisch, James F Wilson, Åsa Johansson, Igor Rudan, Yurii S Aulchenko, Anatoly V Kirichenko, A Cecile J W Janssens, Ritsert C Jansen, Carsten Gnewuch, Francisco S Domingues, Cristian Pattaro, Sarah H Wild, Inger Jonasson, Ozren Polasek, Irina V Zorkoltseva, Albert Hofman, Lennart C Karssen, Maksim Struchalin, James Floyd, Wilmar Igl, Zrinka Biloglav, Linda Broer, Arne Pfeufer, Irene Pichler, Susan Campbell, Ghazal Zaboli, Ivana Kolcic, Fernando Rivadeneira, Jennifer Huffman, Nicholas D Hastie, Andre Uitterlinden, Lude Franke, Christopher S Franklin, Veronique Vitart, DIAGRAM Consortium, Christopher P Nelson, Michael Preuss, CARDIoGRAM Consortium, Joshua C Bis, Christopher J O'Donnell, Nora Franceschini, CHARGE Consortium, Jacqueline C M Witteman, Tatiana Axenovich, Ben A Oostra, Thomas Meitinger, Andrew A Hicks, Caroline Hayward, Alan F Wright, Ulf Gyllensten, Harry Campbell, Gerd Schmitz, EUROSPAN consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3280968?pdf=render

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