Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development.
Bovine leukemia virus (BLV), a common virus of cattle globally, was believed for decades not to infect humans. More recent techniques (in situ PCR and DNA sequencing) enabled detection of BLV in human breast tissue, and determination of its significant association with breast cancer in a US populati...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5480893?pdf=render |
id |
doaj-106ddf48b6374ec0923455ec49df60ec |
---|---|
record_format |
Article |
spelling |
doaj-106ddf48b6374ec0923455ec49df60ec2020-11-24T21:52:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017936710.1371/journal.pone.0179367Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development.Gertrude C BuehringHuaMin ShenDaniel A SchwartzJames S LawsonBovine leukemia virus (BLV), a common virus of cattle globally, was believed for decades not to infect humans. More recent techniques (in situ PCR and DNA sequencing) enabled detection of BLV in human breast tissue, and determination of its significant association with breast cancer in a US population. Using similar techniques to study 96 Australian women, we report here detection of retrotranscribed BLV DNA in breast tissue of 40/50(80%) of women with breast cancer versus 19/46(41%) of women with no history of breast cancer, indicating an age-adjusted odds ratio and confidence interval of 4.72(1.71-13.05). These results corroborate the findings of the previous study of US women with an even higher odds ratio for the Australian population. For 48 of the subjects, paired breast tissue samples, removed 3-10 years apart in two unrelated procedures, were available. For 23/31 (74%) of these, in which the first specimen was diagnosed as nonmalignant (benign or premalignant) and the second as malignant, BLV was already present in benign breast tissue years 3-10 years before the malignancy was diagnosed. This is consistent with the supposition of a causative temporal relationship between BLV infection and subsequent development of cancer.http://europepmc.org/articles/PMC5480893?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gertrude C Buehring HuaMin Shen Daniel A Schwartz James S Lawson |
spellingShingle |
Gertrude C Buehring HuaMin Shen Daniel A Schwartz James S Lawson Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. PLoS ONE |
author_facet |
Gertrude C Buehring HuaMin Shen Daniel A Schwartz James S Lawson |
author_sort |
Gertrude C Buehring |
title |
Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. |
title_short |
Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. |
title_full |
Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. |
title_fullStr |
Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. |
title_full_unstemmed |
Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development. |
title_sort |
bovine leukemia virus linked to breast cancer in australian women and identified before breast cancer development. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Bovine leukemia virus (BLV), a common virus of cattle globally, was believed for decades not to infect humans. More recent techniques (in situ PCR and DNA sequencing) enabled detection of BLV in human breast tissue, and determination of its significant association with breast cancer in a US population. Using similar techniques to study 96 Australian women, we report here detection of retrotranscribed BLV DNA in breast tissue of 40/50(80%) of women with breast cancer versus 19/46(41%) of women with no history of breast cancer, indicating an age-adjusted odds ratio and confidence interval of 4.72(1.71-13.05). These results corroborate the findings of the previous study of US women with an even higher odds ratio for the Australian population. For 48 of the subjects, paired breast tissue samples, removed 3-10 years apart in two unrelated procedures, were available. For 23/31 (74%) of these, in which the first specimen was diagnosed as nonmalignant (benign or premalignant) and the second as malignant, BLV was already present in benign breast tissue years 3-10 years before the malignancy was diagnosed. This is consistent with the supposition of a causative temporal relationship between BLV infection and subsequent development of cancer. |
url |
http://europepmc.org/articles/PMC5480893?pdf=render |
work_keys_str_mv |
AT gertrudecbuehring bovineleukemiaviruslinkedtobreastcancerinaustralianwomenandidentifiedbeforebreastcancerdevelopment AT huaminshen bovineleukemiaviruslinkedtobreastcancerinaustralianwomenandidentifiedbeforebreastcancerdevelopment AT danielaschwartz bovineleukemiaviruslinkedtobreastcancerinaustralianwomenandidentifiedbeforebreastcancerdevelopment AT jamesslawson bovineleukemiaviruslinkedtobreastcancerinaustralianwomenandidentifiedbeforebreastcancerdevelopment |
_version_ |
1725877063848558592 |