Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan
Backgorund: Hepatoblastoma is the most common primary liver malignancy in young children. Methods: To identify predictors of the clinical outcomes of hepatoblastoma, we retrospectively reviewed the medical records of 45 children with hepatoblastoma in the National Taiwan University Hospital from 199...
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doaj-1075828eb130489eb53785c1190cb2c12020-11-25T03:19:27ZengElsevierPediatrics and Neonatology1875-95722020-08-01614393398Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in TaiwanWei-Yun Hsu0Hsiu-Hao Chang1Meng-Yao Lu2Yung-Li Yang3Shiann-Tarng Jou4Huey-Ling Chen5Yen-Hsuan Ni6Hong-Yuan Hsu7Mei-Hwei Chang8Jia-Feng Wu9Department of Pediatrics, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital; No. 8, Chung-Shan S. Rd., Taipei, Taiwan. Fax: +(886-2)- 23114592.Backgorund: Hepatoblastoma is the most common primary liver malignancy in young children. Methods: To identify predictors of the clinical outcomes of hepatoblastoma, we retrospectively reviewed the medical records of 45 children with hepatoblastoma in the National Taiwan University Hospital from 1998 to 2018. All of the children were classified as high risk according to the pretreatment extent of disease (PRETEXT) staging system. The patients’ clinical data (sex, age at diagnosis, PRETEXT status, presence of metastasis or tumor rupture, tumor pathologic type, and clinical outcomes) were analyzed. Results: A total of 45 children with high-risk hepatoblastoma were diagnosed at an average age of 3.2 years. The survival analysis showed that the event-free survival duration was significantly longer in patients aged ≤1.25 years at diagnosis than those >1.25 years (hazard ratio = 2.86, p = 0.036). The absence of initial tumor rupture was associated with longer event-free survival (hazard ratio = 2.74, p = 0.039). Diagnosis at age >1.25 years was correlated with the presence of multifocal liver tumors (p = 0.0002) and tumor rupture at diagnosis (p = 0.02). There was no significant difference in event-free survival between the groups classified as intermediate versus high risk according to the Children's Hepatic tumors International Collaboration hepatoblastoma stratification system (p = 0.13). Conclusions: Diagnosis at ≤ 1.25 years of age and absence of initial tumor rupture were predictive of a good clinical prognosis in Taiwanese children with hepatoblastoma.http://www.sciencedirect.com/science/article/pii/S1875957220300528HepatoblastomaRisk stratificationSIOPEL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Yun Hsu Hsiu-Hao Chang Meng-Yao Lu Yung-Li Yang Shiann-Tarng Jou Huey-Ling Chen Yen-Hsuan Ni Hong-Yuan Hsu Mei-Hwei Chang Jia-Feng Wu |
spellingShingle |
Wei-Yun Hsu Hsiu-Hao Chang Meng-Yao Lu Yung-Li Yang Shiann-Tarng Jou Huey-Ling Chen Yen-Hsuan Ni Hong-Yuan Hsu Mei-Hwei Chang Jia-Feng Wu Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan Pediatrics and Neonatology Hepatoblastoma Risk stratification SIOPEL |
author_facet |
Wei-Yun Hsu Hsiu-Hao Chang Meng-Yao Lu Yung-Li Yang Shiann-Tarng Jou Huey-Ling Chen Yen-Hsuan Ni Hong-Yuan Hsu Mei-Hwei Chang Jia-Feng Wu |
author_sort |
Wei-Yun Hsu |
title |
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan |
title_short |
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan |
title_full |
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan |
title_fullStr |
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan |
title_full_unstemmed |
Clinical risk stratification of children with SIOPEL high-risk hepatoblastoma in Taiwan |
title_sort |
clinical risk stratification of children with siopel high-risk hepatoblastoma in taiwan |
publisher |
Elsevier |
series |
Pediatrics and Neonatology |
issn |
1875-9572 |
publishDate |
2020-08-01 |
description |
Backgorund: Hepatoblastoma is the most common primary liver malignancy in young children. Methods: To identify predictors of the clinical outcomes of hepatoblastoma, we retrospectively reviewed the medical records of 45 children with hepatoblastoma in the National Taiwan University Hospital from 1998 to 2018. All of the children were classified as high risk according to the pretreatment extent of disease (PRETEXT) staging system. The patients’ clinical data (sex, age at diagnosis, PRETEXT status, presence of metastasis or tumor rupture, tumor pathologic type, and clinical outcomes) were analyzed. Results: A total of 45 children with high-risk hepatoblastoma were diagnosed at an average age of 3.2 years. The survival analysis showed that the event-free survival duration was significantly longer in patients aged ≤1.25 years at diagnosis than those >1.25 years (hazard ratio = 2.86, p = 0.036). The absence of initial tumor rupture was associated with longer event-free survival (hazard ratio = 2.74, p = 0.039). Diagnosis at age >1.25 years was correlated with the presence of multifocal liver tumors (p = 0.0002) and tumor rupture at diagnosis (p = 0.02). There was no significant difference in event-free survival between the groups classified as intermediate versus high risk according to the Children's Hepatic tumors International Collaboration hepatoblastoma stratification system (p = 0.13). Conclusions: Diagnosis at ≤ 1.25 years of age and absence of initial tumor rupture were predictive of a good clinical prognosis in Taiwanese children with hepatoblastoma. |
topic |
Hepatoblastoma Risk stratification SIOPEL |
url |
http://www.sciencedirect.com/science/article/pii/S1875957220300528 |
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