Borrelia burgdorferi-specific IgA in Lyme Disease
The laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear. The production of intrathecal IgA has been noted in patie...
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doaj-107c24051359491b98340b5b0c0c76b72020-11-25T01:01:08ZengElsevierEBioMedicine2352-39642017-05-0119C919710.1016/j.ebiom.2017.04.025Borrelia burgdorferi-specific IgA in Lyme DiseaseChristina D'Arco0Raymond J. Dattwyler1Paul M. Arnaboldi2Department of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, United StatesDepartment of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, United StatesDepartment of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY 10595, United StatesThe laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear. The production of intrathecal IgA has been noted in patients with the late Lyme disease manifestation, neuroborreliosis, but production of antigen-specific IgA during early disease has not been evaluated. In the current study, we assessed serum IgA binding to the B. burgdorferi peptide antigens, C6, the target of the FDA-cleared C6 EIA, and FlaB(211-223)-modVlsE(275-291), a peptide containing a Borrelia flagellin epitope linked to a modified VlsE sequence, in patients with early and late Lyme disease. Specific IgA was detected in 59 of 152 serum samples (38.8%) from early Lyme disease patients. Approximately 50% of early Lyme disease patients who were seropositive for peptide-specific IgM and/or IgG were also seropositive for peptide-specific IgA. In a subpopulation of patients, high peptide-specific IgA could be correlated with disseminated disease, defined as multiple erythema migrans lesions, and neurological disease complications. These results suggest that there may be an association between elevated levels of antigen-specific IgA and particular disease manifestations in some patients with early Lyme disease.http://www.sciencedirect.com/science/article/pii/S2352396417301809Lyme diseaseIgABorrelia burgdorferiLyme neuroborreliosisErythema migrans |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christina D'Arco Raymond J. Dattwyler Paul M. Arnaboldi |
spellingShingle |
Christina D'Arco Raymond J. Dattwyler Paul M. Arnaboldi Borrelia burgdorferi-specific IgA in Lyme Disease EBioMedicine Lyme disease IgA Borrelia burgdorferi Lyme neuroborreliosis Erythema migrans |
author_facet |
Christina D'Arco Raymond J. Dattwyler Paul M. Arnaboldi |
author_sort |
Christina D'Arco |
title |
Borrelia burgdorferi-specific IgA in Lyme Disease |
title_short |
Borrelia burgdorferi-specific IgA in Lyme Disease |
title_full |
Borrelia burgdorferi-specific IgA in Lyme Disease |
title_fullStr |
Borrelia burgdorferi-specific IgA in Lyme Disease |
title_full_unstemmed |
Borrelia burgdorferi-specific IgA in Lyme Disease |
title_sort |
borrelia burgdorferi-specific iga in lyme disease |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2017-05-01 |
description |
The laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear. The production of intrathecal IgA has been noted in patients with the late Lyme disease manifestation, neuroborreliosis, but production of antigen-specific IgA during early disease has not been evaluated. In the current study, we assessed serum IgA binding to the B. burgdorferi peptide antigens, C6, the target of the FDA-cleared C6 EIA, and FlaB(211-223)-modVlsE(275-291), a peptide containing a Borrelia flagellin epitope linked to a modified VlsE sequence, in patients with early and late Lyme disease. Specific IgA was detected in 59 of 152 serum samples (38.8%) from early Lyme disease patients. Approximately 50% of early Lyme disease patients who were seropositive for peptide-specific IgM and/or IgG were also seropositive for peptide-specific IgA. In a subpopulation of patients, high peptide-specific IgA could be correlated with disseminated disease, defined as multiple erythema migrans lesions, and neurological disease complications. These results suggest that there may be an association between elevated levels of antigen-specific IgA and particular disease manifestations in some patients with early Lyme disease. |
topic |
Lyme disease IgA Borrelia burgdorferi Lyme neuroborreliosis Erythema migrans |
url |
http://www.sciencedirect.com/science/article/pii/S2352396417301809 |
work_keys_str_mv |
AT christinadarco borreliaburgdorferispecificigainlymedisease AT raymondjdattwyler borreliaburgdorferispecificigainlymedisease AT paulmarnaboldi borreliaburgdorferispecificigainlymedisease |
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