Histomorphological changes in thymus and spleen after cyclooxygenase inhibitors treatment

• Main Authors: Poeta O.N., Gorbunov A.A., Mamchur V.Yo.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2009-01-01
• Series: Морфологія
• Subjects: cyclooxygenase inhibitors; diclofenac; meloxicam; celecoxib; rofecoxib; thymus; spleen; lymphocytes
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2009-03-03/09pomvic.pdf

The influence of cyclooxygenase inhibitors on the lymphoid organs histomorphology has been examined in the matured outbread white mice. Diclofenac, meloxicam, celecoxib, but not rofecoxib has shown depressive action on the im-munocompetetive organs histomorphologic structure. Macroscopic study has revealed a decrease in the weight of the spleen and thymus. Light microscopy has shown a decrease in the number of thymocytes, due to degradation of cortex area. In the lobular medulla it has been observed microcirculation changes in the view of venules and capillaries distention, arteriolar wall thickening. In the spleen it has been shown a decrease in the white pulp volume, disappearing of the reactive centers in follicles. Also subcapsular edema and relative stroma volume increase has been seen frequently. The use of highly selective COG-2 inhibitor rofecoxib has not revealed statistically truthful changes in microscopic examination in comparison to the control group. That could vote for the absence of depressive action on the immune organ histomorphologic structure.