Simultaneous Quantification of Protein Binding Kinetics in Whole Cells with Surface Plasmon Resonance Imaging and Edge Deformation Tracking

Simultaneous Quantification of Protein Binding Kinetics in Whole Cells with Surface Plasmon Resonance Imaging and Edge Deformation Tracking

Most drugs work by binding to receptors on the cell surface. Quantification of binding kinetics between drug and membrane protein is an essential step in drug discovery. Current methods for measuring binding kinetics involve extracting the membrane protein and labeling, and both have issues. Surface...

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Bibliographic Details
Main Authors: Wenwen Jing, Ashley Hunt, Nongjian Tao, Fenni Zhang, Shaopeng Wang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Membranes
Subjects:
binding kinetics
surface plasmonic resonance
cell edge tracking
whole cell
wheat germ agglutinin
Online Access:https://www.mdpi.com/2077-0375/10/9/247

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