Zeaxanthin Inhibits Hypoxia-Induced VEGF Secretion by RPE Cells through Decreased Protein Levels of Hypoxia-Inducible Factors-1α
Hypoxia is the most important stimulus leading to upregulation of VEGF in the retina and this is caused by accumulation of hypoxia-inducible factors-1α (HIF-1α) protein. The effects of zeaxanthin, a natural phytochemical, on the VEGF and HIF-1α expression in the primary culture of human retinal pigm...
Main Authors: | Richard Rosen, Tommaso Vagaggini, Yueqin Chen, Dan-Ning Hu |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2015/687386 |
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