Fabrication and characterization of electrospun poly(e-caprolactone) fibrous membrane with antibacterial functionality

• Main Authors: Idris Cerkez, Ayse Sezer, Sukhwinder K. Bhullar
• Format: Article
• Language: English
• Published: The Royal Society 2017-01-01
• Series: Royal Society Open Science
• Subjects: electrospinning; membranes; biodegradable
• Online Access: https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.160911

This research study is mainly targeted on fabrication and characterization of antibacterial poly(e-caprolactone) (PCL) based fibrous membrane containing silver chloride particles. Micro/nano fibres were produced by electrospinning and characterized with TGA, DSC, SEM and mechanical analysis. It was found that addition of silver particles slightly reduced onset of thermal degradation and increased crystallization temperature of neat PCL. Silver-loaded samples exhibited higher tensile stress and lower strain revealing that the particles behaved as reinforcing agent. Moreover, addition of silver chloride resulted in beaded surface texture and formation of finer fibres as opposed to the neat. Antibacterial properties were tested against Gram-negative and Gram-positive bacteria and remarkable biocidal functionalities were obtained with about six logs reduction of Staphylococcus aureus and Escherichia coli O157:H7.