Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process

Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process

In this work, a multi-analytical approach involving nitrogen porosimetry, small angle neutron and X-ray scattering, Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies, X-ray diffraction, thermal analysis and electron microscopy was applied to organically modified s...

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Main Authors: Adél Len, Giuseppe Paladini, Loránd Románszki, Ana-Maria Putz, László Almásy, Krisztina László, Szabolcs Bálint, Andraž Krajnc, Manfred Kriechbaum, Andrei Kuncser, József Kalmár, Zoltán Dudás
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
hybrid silica materials
sol–gel technique
structural characterization
nanostructure
controlled release
Captopril
Online Access:https://www.mdpi.com/1422-0067/22/17/9197
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spelling doaj-10a9101fcc924285b64f674ba28bcd042021-09-09T13:46:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01229197919710.3390/ijms22179197Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel ProcessAdél Len0Giuseppe Paladini1Loránd Románszki2Ana-Maria Putz3László Almásy4Krisztina László5Szabolcs Bálint6Andraž Krajnc7Manfred Kriechbaum8Andrei Kuncser9József Kalmár10Zoltán Dudás11Neutron Spectroscopy Department, Centre for Energy Research, Konkoly-Thege 29-33, 1121 Budapest, HungaryDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, ItalyFunctional Interfaces Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary“Coriolan Drăgulescu” Institute of Chemistry Timisoara, 24 Mihai Viteazul Ave., 300223 Timisoara, RomaniaNeutron Spectroscopy Department, Centre for Energy Research, Konkoly-Thege 29-33, 1121 Budapest, HungaryDepartment of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, 1521 Budapest, HungarySemilab Semiconductor Physics Laboratory Co. Ltd., 4/A Prielle Kornelia Str., 1117 Budapest, HungaryDepartment of Inorganic Chemistry and Technology, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, SloveniaInstitute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, AustriaNational Institute of Materials Physics, 405A Atomistilor Street, 077125 Magurele, RomaniaMTA-DE ELKH Homogeneous Catalysis and Reaction Mechanisms Research Group, Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, 4032 Debrecen, HungaryNeutron Spectroscopy Department, Centre for Energy Research, Konkoly-Thege 29-33, 1121 Budapest, HungaryIn this work, a multi-analytical approach involving nitrogen porosimetry, small angle neutron and X-ray scattering, Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies, X-ray diffraction, thermal analysis and electron microscopy was applied to organically modified silica-based xerogels obtained through the sol–gel process. Starting from a tetraethoxysilane (TEOS) precursor, methyltriethoxysilane (MTES) was added to the reaction mixture at two different pH values (2.0 and 4.5) producing hybrid xerogels with different TEOS/MTES molar ratios. Significant differences in the structure were revealed in terms of the chemical composition of the silica network, hydrophilic/hydrophobic profile, particle dimension, pore shape/size and surface characteristics. The combined use of structural characterization methods allowed us to reveal a relation between the cavity dimensions, the synthesis pH value and the grade of methyl substitution. The effect of the structural properties on the controlled Captopril release efficiency has also been tested. This knowledge facilitates tailoring the pore network for specific usage in biological/medical applications. Knowledge on structural aspects, as reported in this work, represents a key starting point for the production of high-performance silica-based hybrid materials showing enhanced efficacy compared to bare silica prepared using only TEOS.https://www.mdpi.com/1422-0067/22/17/9197hybrid silica materialssol–gel techniquestructural characterizationnanostructurecontrolled releaseCaptopril
collection DOAJ
language English
format Article
sources DOAJ
author Adél Len
Giuseppe Paladini
Loránd Románszki
Ana-Maria Putz
László Almásy
Krisztina László
Szabolcs Bálint
Andraž Krajnc
Manfred Kriechbaum
Andrei Kuncser
József Kalmár
Zoltán Dudás
spellingShingle Adél Len
Giuseppe Paladini
Loránd Románszki
Ana-Maria Putz
László Almásy
Krisztina László
Szabolcs Bálint
Andraž Krajnc
Manfred Kriechbaum
Andrei Kuncser
József Kalmár
Zoltán Dudás
Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
International Journal of Molecular Sciences
hybrid silica materials
sol–gel technique
structural characterization
nanostructure
controlled release
Captopril
author_facet Adél Len
Giuseppe Paladini
Loránd Románszki
Ana-Maria Putz
László Almásy
Krisztina László
Szabolcs Bálint
Andraž Krajnc
Manfred Kriechbaum
Andrei Kuncser
József Kalmár
Zoltán Dudás
author_sort Adél Len
title Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
title_short Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
title_full Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
title_fullStr Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
title_full_unstemmed Physicochemical Characterization and Drug Release Properties of Methyl-Substituted Silica Xerogels Made Using Sol–Gel Process
title_sort physicochemical characterization and drug release properties of methyl-substituted silica xerogels made using sol–gel process
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-08-01
description In this work, a multi-analytical approach involving nitrogen porosimetry, small angle neutron and X-ray scattering, Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies, X-ray diffraction, thermal analysis and electron microscopy was applied to organically modified silica-based xerogels obtained through the sol–gel process. Starting from a tetraethoxysilane (TEOS) precursor, methyltriethoxysilane (MTES) was added to the reaction mixture at two different pH values (2.0 and 4.5) producing hybrid xerogels with different TEOS/MTES molar ratios. Significant differences in the structure were revealed in terms of the chemical composition of the silica network, hydrophilic/hydrophobic profile, particle dimension, pore shape/size and surface characteristics. The combined use of structural characterization methods allowed us to reveal a relation between the cavity dimensions, the synthesis pH value and the grade of methyl substitution. The effect of the structural properties on the controlled Captopril release efficiency has also been tested. This knowledge facilitates tailoring the pore network for specific usage in biological/medical applications. Knowledge on structural aspects, as reported in this work, represents a key starting point for the production of high-performance silica-based hybrid materials showing enhanced efficacy compared to bare silica prepared using only TEOS.
topic hybrid silica materials
sol–gel technique
structural characterization
nanostructure
controlled release
Captopril
url https://www.mdpi.com/1422-0067/22/17/9197
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