An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.

An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.

Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5. We o...

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Bibliographic Details
Main Authors: Mirta M L Sousa, Kamila Anna Zub, Per Arne Aas, Audun Hanssen-Bauer, Aida Demirovic, Antonio Sarno, Erming Tian, Nina B Liabakk, Geir Slupphaug
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566207?pdf=render

Internet

http://europepmc.org/articles/PMC3566207?pdf=render

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