An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance. Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5. We o...
Main Authors: | Mirta M L Sousa, Kamila Anna Zub, Per Arne Aas, Audun Hanssen-Bauer, Aida Demirovic, Antonio Sarno, Erming Tian, Nina B Liabakk, Geir Slupphaug |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3566207?pdf=render |
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