Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]

Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]

In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional cand...

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Main Authors: Wim E. Crusio, Esha Dhawan, Elissa J. Chesler, Anna Delprato
Format: Article
Language:English
Published: F1000 Research Ltd 2016-09-01
Series:F1000Research
Subjects:
Neurogenetics
Online Access:http://f1000research.com/articles/5-2156/v1
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spelling doaj-10c462d3a8754e888b330348777a1da32020-11-25T04:00:21ZengF1000 Research LtdF1000Research2046-14022016-09-01510.12688/f1000research.9484.110214Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]Wim E. Crusio0Esha Dhawan1Elissa J. Chesler2Anna Delprato3Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, CNRS, Pessac, FranceBioScience Project, Wakefield, USAJackson Laboratory, Bar Harbor, USABioScience Project, Wakefield, USAIn this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.http://f1000research.com/articles/5-2156/v1Neurogenetics
collection DOAJ
language English
format Article
sources DOAJ
author Wim E. Crusio
Esha Dhawan
Elissa J. Chesler
Anna Delprato
spellingShingle Wim E. Crusio
Esha Dhawan
Elissa J. Chesler
Anna Delprato
Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
F1000Research
Neurogenetics
author_facet Wim E. Crusio
Esha Dhawan
Elissa J. Chesler
Anna Delprato
author_sort Wim E. Crusio
title Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
title_short Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
title_full Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
title_fullStr Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
title_full_unstemmed Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 1; referees: 2 approved]
title_sort analysis of morphine responses in mice reveals a qtl on chromosome 7 [version 1; referees: 2 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2016-09-01
description In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.
topic Neurogenetics
url http://f1000research.com/articles/5-2156/v1
work_keys_str_mv AT wimecrusio analysisofmorphineresponsesinmicerevealsaqtlonchromosome7version1referees2approved
AT eshadhawan analysisofmorphineresponsesinmicerevealsaqtlonchromosome7version1referees2approved
AT elissajchesler analysisofmorphineresponsesinmicerevealsaqtlonchromosome7version1referees2approved
AT annadelprato analysisofmorphineresponsesinmicerevealsaqtlonchromosome7version1referees2approved
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