Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis

Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis

Osteoporosis, mainly caused by osteoclast-induced bone resorption, has become a major health problem in post-menopausal women and the elderly. Growing evidence indicates that inhibiting osteoclastogenesis is an efficient approach to develop alternative therapeutic agents for treating osteoporosis. I...

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Bibliographic Details
Main Authors: Chao Jiang, Qingliang Ma, Shiyu Wang, Yang Shen, An Qin, Shunwu Fan, Zhiwei Jie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
oxymatrine
osteoclast
ROS
SREBP2
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.684007/full

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