Conditionally replicating adenovirus prevents pluripotent stem cellâderived teratoma by specifically eliminating undifferentiated cells
Incomplete abolition of tumorigenicity creates potential safety concerns in clinical trials of regenerative medicine based on human pluripotent stem cells (hPSCs). Here, we demonstrate that conditionally replicating adenoviruses that specifically target cancers using multiple factors (m-CRAs), origi...
Main Authors: | Kaoru Mitsui, Kanako Ide, Akiko Takayama, Tadahisa Wada, Rie Irie, Ken-ichiro Kosai |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-01-01
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Series: | Molecular Therapy: Methods & Clinical Development |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050116300389 |
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