Metabolic engineering of microorganisms for production of aromatic compounds
Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercializ...
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doaj-10e4dec876444c5c8d662d054d2b04722020-11-25T01:27:38ZengBMCMicrobial Cell Factories1475-28592019-02-0118112910.1186/s12934-019-1090-4Metabolic engineering of microorganisms for production of aromatic compoundsDamla Huccetogullari0Zi Wei Luo1Sang Yup Lee2Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program) and Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST)Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efficient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based production of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including l-phenylalanine, l-tyrosine and l-tryptophan. It is expected that more and more engineered microorganisms capable of efficiently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass.http://link.springer.com/article/10.1186/s12934-019-1090-4Aromatic compoundsMetabolic engineeringSynthetic biologyShikimate pathwayPhenylalanineTyrosine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damla Huccetogullari Zi Wei Luo Sang Yup Lee |
spellingShingle |
Damla Huccetogullari Zi Wei Luo Sang Yup Lee Metabolic engineering of microorganisms for production of aromatic compounds Microbial Cell Factories Aromatic compounds Metabolic engineering Synthetic biology Shikimate pathway Phenylalanine Tyrosine |
author_facet |
Damla Huccetogullari Zi Wei Luo Sang Yup Lee |
author_sort |
Damla Huccetogullari |
title |
Metabolic engineering of microorganisms for production of aromatic compounds |
title_short |
Metabolic engineering of microorganisms for production of aromatic compounds |
title_full |
Metabolic engineering of microorganisms for production of aromatic compounds |
title_fullStr |
Metabolic engineering of microorganisms for production of aromatic compounds |
title_full_unstemmed |
Metabolic engineering of microorganisms for production of aromatic compounds |
title_sort |
metabolic engineering of microorganisms for production of aromatic compounds |
publisher |
BMC |
series |
Microbial Cell Factories |
issn |
1475-2859 |
publishDate |
2019-02-01 |
description |
Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efficient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based production of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including l-phenylalanine, l-tyrosine and l-tryptophan. It is expected that more and more engineered microorganisms capable of efficiently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass. |
topic |
Aromatic compounds Metabolic engineering Synthetic biology Shikimate pathway Phenylalanine Tyrosine |
url |
http://link.springer.com/article/10.1186/s12934-019-1090-4 |
work_keys_str_mv |
AT damlahuccetogullari metabolicengineeringofmicroorganismsforproductionofaromaticcompounds AT ziweiluo metabolicengineeringofmicroorganismsforproductionofaromaticcompounds AT sangyuplee metabolicengineeringofmicroorganismsforproductionofaromaticcompounds |
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