The ubiquitin-proteasome system in glioma cell cycle control
<p>Abstract</p> <p>A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, e...
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doaj-10ed6d57642541d4886e9416f2dc97982020-11-25T00:15:11ZengBMCCell Division1747-10282012-07-01711810.1186/1747-1028-7-18The ubiquitin-proteasome system in glioma cell cycle controlVlachostergios Panagiotis JVoutsadakis Ioannis APapandreou Christos N<p>Abstract</p> <p>A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.</p> http://www.celldiv.com/content/7/1/18Ubiquitin-proteasome systemGliomaProteasome inhibitorsUbiquitinCell cycle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vlachostergios Panagiotis J Voutsadakis Ioannis A Papandreou Christos N |
spellingShingle |
Vlachostergios Panagiotis J Voutsadakis Ioannis A Papandreou Christos N The ubiquitin-proteasome system in glioma cell cycle control Cell Division Ubiquitin-proteasome system Glioma Proteasome inhibitors Ubiquitin Cell cycle |
author_facet |
Vlachostergios Panagiotis J Voutsadakis Ioannis A Papandreou Christos N |
author_sort |
Vlachostergios Panagiotis J |
title |
The ubiquitin-proteasome system in glioma cell cycle control |
title_short |
The ubiquitin-proteasome system in glioma cell cycle control |
title_full |
The ubiquitin-proteasome system in glioma cell cycle control |
title_fullStr |
The ubiquitin-proteasome system in glioma cell cycle control |
title_full_unstemmed |
The ubiquitin-proteasome system in glioma cell cycle control |
title_sort |
ubiquitin-proteasome system in glioma cell cycle control |
publisher |
BMC |
series |
Cell Division |
issn |
1747-1028 |
publishDate |
2012-07-01 |
description |
<p>Abstract</p> <p>A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.</p> |
topic |
Ubiquitin-proteasome system Glioma Proteasome inhibitors Ubiquitin Cell cycle |
url |
http://www.celldiv.com/content/7/1/18 |
work_keys_str_mv |
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