Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that two classes of luminal progenitors exist within a tumor. N...

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Bibliographic Details
Main Authors: Supreet Agarwal, Paul G. Hynes, Heather S. Tillman, Ross Lake, Wassim G. Abou-Kheir, Lei Fang, Orla M. Casey, Amir H. Ameri, Philip L. Martin, Juan Juan Yin, Phillip J. Iaquinta, Wouter R. Karthaus, Hans C. Clevers, Charles L. Sawyers, Kathleen Kelly
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Subjects:
prostate cancer
stem/progenitor cells
heterogeneity
castration
luminal
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012851

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http://www.sciencedirect.com/science/article/pii/S2211124715012851

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