Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) are common complications after anesthesia, but no study has considered the effects of a proton pump inhibitor (PPI) and gastroesophageal reflux disease (GERD) on PONV at the same time. Thus, we investigated the effects of a PPI and GERD on PONV. Patients aged...
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doaj-10f77f024989432b8a8d993d8e3f15d62020-11-25T02:01:59ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019382510.3390/jcm9030825jcm9030825Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and VomitingYoung Suk Kwon0Jun Woo Choi1Ho Seok Lee2Jong Ho Kim3Youngmi Kim4Jae Jun Lee5Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, KoreaInstitute of New Frontier Research Team, Hallym University, Chuncheon 24253, KoreaDepartment of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, KoreaPostoperative nausea and vomiting (PONV) are common complications after anesthesia, but no study has considered the effects of a proton pump inhibitor (PPI) and gastroesophageal reflux disease (GERD) on PONV at the same time. Thus, we investigated the effects of a PPI and GERD on PONV. Patients aged ≥18 years who underwent general anesthesia between 2010 and 2019 were enrolled. In total, 202,439 patients were included and 21,361 In a multivariate analysis, the OR for PONV was higher in subjects with GERD (OR, 1.157; 95% CI, 1.032−1.298; <i>p</i> = 0.012). The OR was lower for subjects with taking a PPI (OR, 0.890; 95% CI, 0.832−0.953; <i>p</i> < 0.0001). In patients without GERD, the incidence of PONV was lower when lansoprazole (OR, 0.801; 95% CI, 0.718−0.894; <i>p</i> < 0.0001), pantoprazole (OR, 0.856; 95% CI, 0.748−0.980; <i>p</i> = 0.025) and ilaprazole (OR, 0.391; 95% CI, 0.158−0.966; <i>p</i> = 0.042) were taken. However, in GERD patients, all PPIs did not show reducing the incidence of PONV. Taken together, the results show that a lansoprazole, pantoprazole, and ilaprazole reduced PONV in patients without GERD, and PPI could not reduce PONV in patients with GERD.https://www.mdpi.com/2077-0383/9/3/825proton pump inhibitorgastroesophageal reflux diseasepostoperative nausea and vomiting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young Suk Kwon Jun Woo Choi Ho Seok Lee Jong Ho Kim Youngmi Kim Jae Jun Lee |
spellingShingle |
Young Suk Kwon Jun Woo Choi Ho Seok Lee Jong Ho Kim Youngmi Kim Jae Jun Lee Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting Journal of Clinical Medicine proton pump inhibitor gastroesophageal reflux disease postoperative nausea and vomiting |
author_facet |
Young Suk Kwon Jun Woo Choi Ho Seok Lee Jong Ho Kim Youngmi Kim Jae Jun Lee |
author_sort |
Young Suk Kwon |
title |
Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting |
title_short |
Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting |
title_full |
Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting |
title_fullStr |
Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting |
title_full_unstemmed |
Effect of a Preoperative Proton Pump Inhibitor and Gastroesophageal Reflux Disease on Postoperative Nausea and Vomiting |
title_sort |
effect of a preoperative proton pump inhibitor and gastroesophageal reflux disease on postoperative nausea and vomiting |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
Postoperative nausea and vomiting (PONV) are common complications after anesthesia, but no study has considered the effects of a proton pump inhibitor (PPI) and gastroesophageal reflux disease (GERD) on PONV at the same time. Thus, we investigated the effects of a PPI and GERD on PONV. Patients aged ≥18 years who underwent general anesthesia between 2010 and 2019 were enrolled. In total, 202,439 patients were included and 21,361 In a multivariate analysis, the OR for PONV was higher in subjects with GERD (OR, 1.157; 95% CI, 1.032−1.298; <i>p</i> = 0.012). The OR was lower for subjects with taking a PPI (OR, 0.890; 95% CI, 0.832−0.953; <i>p</i> < 0.0001). In patients without GERD, the incidence of PONV was lower when lansoprazole (OR, 0.801; 95% CI, 0.718−0.894; <i>p</i> < 0.0001), pantoprazole (OR, 0.856; 95% CI, 0.748−0.980; <i>p</i> = 0.025) and ilaprazole (OR, 0.391; 95% CI, 0.158−0.966; <i>p</i> = 0.042) were taken. However, in GERD patients, all PPIs did not show reducing the incidence of PONV. Taken together, the results show that a lansoprazole, pantoprazole, and ilaprazole reduced PONV in patients without GERD, and PPI could not reduce PONV in patients with GERD. |
topic |
proton pump inhibitor gastroesophageal reflux disease postoperative nausea and vomiting |
url |
https://www.mdpi.com/2077-0383/9/3/825 |
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