Growth Hormone Deficiency Is Frequent After Recent Stroke
Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke.Methods: We perform an argin...
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doaj-1102550e27f241fb9e6d4abeed2d39ed2020-11-24T23:26:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-09-01910.3389/fneur.2018.00713403044Growth Hormone Deficiency Is Frequent After Recent StrokeThomas Lillicrap0Carlos Garcia-Esperon1Frederick Rohan Walker2Lin Kooi Ong3Michael Nilsson4Neil Spratt5Neil Spratt6Christopher R. Levi7Christopher R. Levi8Mark Parsons9Mark Parsons10Jörgen Isgaard11Jörgen Isgaard12Andrew Bivard13Andrew Bivard14Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaDepartment of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaDepartment of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaDepartment of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaDepartment of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaDepartment of Internal Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SwedenDepartment of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, AustraliaHunter Medical Research Institute, University of NewcastleNewcastle, NSW, AustraliaIntroduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke.Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset.Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7–16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges.Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.https://www.frontiersin.org/article/10.3389/fneur.2018.00713/fullischemic strokegrowth hormoneneuro recoveryrehabilitationcognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Lillicrap Carlos Garcia-Esperon Frederick Rohan Walker Lin Kooi Ong Michael Nilsson Neil Spratt Neil Spratt Christopher R. Levi Christopher R. Levi Mark Parsons Mark Parsons Jörgen Isgaard Jörgen Isgaard Andrew Bivard Andrew Bivard |
spellingShingle |
Thomas Lillicrap Carlos Garcia-Esperon Frederick Rohan Walker Lin Kooi Ong Michael Nilsson Neil Spratt Neil Spratt Christopher R. Levi Christopher R. Levi Mark Parsons Mark Parsons Jörgen Isgaard Jörgen Isgaard Andrew Bivard Andrew Bivard Growth Hormone Deficiency Is Frequent After Recent Stroke Frontiers in Neurology ischemic stroke growth hormone neuro recovery rehabilitation cognition |
author_facet |
Thomas Lillicrap Carlos Garcia-Esperon Frederick Rohan Walker Lin Kooi Ong Michael Nilsson Neil Spratt Neil Spratt Christopher R. Levi Christopher R. Levi Mark Parsons Mark Parsons Jörgen Isgaard Jörgen Isgaard Andrew Bivard Andrew Bivard |
author_sort |
Thomas Lillicrap |
title |
Growth Hormone Deficiency Is Frequent After Recent Stroke |
title_short |
Growth Hormone Deficiency Is Frequent After Recent Stroke |
title_full |
Growth Hormone Deficiency Is Frequent After Recent Stroke |
title_fullStr |
Growth Hormone Deficiency Is Frequent After Recent Stroke |
title_full_unstemmed |
Growth Hormone Deficiency Is Frequent After Recent Stroke |
title_sort |
growth hormone deficiency is frequent after recent stroke |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-09-01 |
description |
Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke.Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset.Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7–16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges.Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery. |
topic |
ischemic stroke growth hormone neuro recovery rehabilitation cognition |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.00713/full |
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