Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms
Icariin has a variety of biological activities, such as lipid-lowering effects, and has attracted widespread attention in recent years. However, it is not clear whether lipid-lowering effect is that multiple metabolites or a particular component plays a major role. It is known that icariin has a var...
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doaj-110610b5594a4f43892b50267e0642e42021-05-20T07:43:45ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-11-01131110675Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanismsMiao Wang0Hongyan Gao1Weihong Li2Bin Wu3Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR ChinaChongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China; Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611137, PR ChinaBasic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611137, PR China; Corresponding author at: Basic Medical College, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Avenue, Wenjiang District, Chengdu, Sichuan Province, 611137, PR China.Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China; Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China; Corresponding author at: Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6, Pan Xi Qi Zhi Road, Jiangbei District, Chongqing, 400021, PR China.Icariin has a variety of biological activities, such as lipid-lowering effects, and has attracted widespread attention in recent years. However, it is not clear whether lipid-lowering effect is that multiple metabolites or a particular component plays a major role. It is known that icariin has a variety of metabolites in the body, including icariside I, icariside II, icaritin, desmethylicaritin, and other metabolites. Many of these studies have shown that the metabolites of icariin have a lipid-lowering effect. This paper focuses on the lipid-regulating effects of icariin and its metabolites in vitro and in vivo, and highlights the mechanisms involved. Icariin may have potential in the development of therapeutic strategies to regulate lipid metabolism.http://www.sciencedirect.com/science/article/pii/S0753332220308684IcariinMetaboliteLipid metabolismPharmacologyMolecular mechanism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miao Wang Hongyan Gao Weihong Li Bin Wu |
spellingShingle |
Miao Wang Hongyan Gao Weihong Li Bin Wu Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms Biomedicine & Pharmacotherapy Icariin Metabolite Lipid metabolism Pharmacology Molecular mechanism |
author_facet |
Miao Wang Hongyan Gao Weihong Li Bin Wu |
author_sort |
Miao Wang |
title |
Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms |
title_short |
Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms |
title_full |
Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms |
title_fullStr |
Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms |
title_full_unstemmed |
Icariin and its metabolites regulate lipid metabolism: From effects to molecular mechanisms |
title_sort |
icariin and its metabolites regulate lipid metabolism: from effects to molecular mechanisms |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-11-01 |
description |
Icariin has a variety of biological activities, such as lipid-lowering effects, and has attracted widespread attention in recent years. However, it is not clear whether lipid-lowering effect is that multiple metabolites or a particular component plays a major role. It is known that icariin has a variety of metabolites in the body, including icariside I, icariside II, icaritin, desmethylicaritin, and other metabolites. Many of these studies have shown that the metabolites of icariin have a lipid-lowering effect. This paper focuses on the lipid-regulating effects of icariin and its metabolites in vitro and in vivo, and highlights the mechanisms involved. Icariin may have potential in the development of therapeutic strategies to regulate lipid metabolism. |
topic |
Icariin Metabolite Lipid metabolism Pharmacology Molecular mechanism |
url |
http://www.sciencedirect.com/science/article/pii/S0753332220308684 |
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