Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME)
Numerous microbiotas, which play important roles in health, inhabit the human gut. A traditional Chinese medicine dietary therapy (TCMDT) diet, consisted of whole grains and traditional Chinese medicines, is traditionally used to lessen hyperglycemia and reduce obesity. The Simulator of the human in...
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doaj-11077cc7a7fe457487a40716b53fbb962021-04-30T07:17:21ZengElsevierJournal of Functional Foods1756-46462019-11-0162Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME)Ruiyu Wu0Xin Tang1Xincong Kang2Yushuang Luo3Lei Wang4Jian Li5Xiyang Wu6Dongbo Liu7Horticulture and Landscape College, Hunan Agricultural University, Changsha 410128, China; State Key Laboratory of Subhealth Intervention Technology, Changsha 410128, ChinaDepartment of Food Science and Engineering, Jinan University, Guangzhou 510632, ChinaHorticulture and Landscape College, Hunan Agricultural University, Changsha 410128, China; State Key Laboratory of Subhealth Intervention Technology, Changsha 410128, ChinaHorticulture and Landscape College, Hunan Agricultural University, Changsha 410128, China; State Key Laboratory of Subhealth Intervention Technology, Changsha 410128, ChinaLiaoning Shengqi Heaven Biomedical Technology Co., Ltd., Shenyang 110000, ChinaHunan Hyso Environmental Biotechnology Co., Ltd., Changsha 410205, ChinaDepartment of Food Science and Engineering, Jinan University, Guangzhou 510632, ChinaHorticulture and Landscape College, Hunan Agricultural University, Changsha 410128, China; State Key Laboratory of Subhealth Intervention Technology, Changsha 410128, China; Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China; Hunan Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Changsha 410128, China; Corresponding author at: Horticulture and Landscape College, Hunan Agricultural University, Changsha 410128, China.Numerous microbiotas, which play important roles in health, inhabit the human gut. A traditional Chinese medicine dietary therapy (TCMDT) diet, consisted of whole grains and traditional Chinese medicines, is traditionally used to lessen hyperglycemia and reduce obesity. The Simulator of the human intestinal microbial ecosystem (SHIME) was used for studying the effect of the TCMDT diet on gut microbiota and short chain fatty acids. The TCMDT diet increased diabetes-improving microbiota (Coriobacteriaceae, Bacteroidaceae, and Peptostreptococcaceae) by 7–26 times and health-related microbiota (Rikenellaceae, Bifidobacteria, Actinobacteria) by 4–300 times. The short chain fatty acids-producers, Bacteroides and Parabacteroides were elevated after intervention. This diet significantly increased acetate (from 2.23 to 36.77 mmol/L), propionate (from 2.85 to 33.93 mmol/L), and butyrate (from 0.89 to 6.96 mmol/L), which are the major short chain fatty acids. Our study provides novel perspective into the role of gut microbiota modulation during TCMDT diet intervention.http://www.sciencedirect.com/science/article/pii/S1756464619304797Whole grainsTraditional Chinese medicine dietary therapyGanoderma lucidum polysaccharidesChronic diseases intervention |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruiyu Wu Xin Tang Xincong Kang Yushuang Luo Lei Wang Jian Li Xiyang Wu Dongbo Liu |
spellingShingle |
Ruiyu Wu Xin Tang Xincong Kang Yushuang Luo Lei Wang Jian Li Xiyang Wu Dongbo Liu Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) Journal of Functional Foods Whole grains Traditional Chinese medicine dietary therapy Ganoderma lucidum polysaccharides Chronic diseases intervention |
author_facet |
Ruiyu Wu Xin Tang Xincong Kang Yushuang Luo Lei Wang Jian Li Xiyang Wu Dongbo Liu |
author_sort |
Ruiyu Wu |
title |
Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) |
title_short |
Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) |
title_full |
Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) |
title_fullStr |
Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) |
title_full_unstemmed |
Effect of a Chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (SHIME) |
title_sort |
effect of a chinese medical nutrition therapy diet on gut microbiota and short chain fatty acids in the simulator of the human intestinal microbial ecosystem (shime) |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2019-11-01 |
description |
Numerous microbiotas, which play important roles in health, inhabit the human gut. A traditional Chinese medicine dietary therapy (TCMDT) diet, consisted of whole grains and traditional Chinese medicines, is traditionally used to lessen hyperglycemia and reduce obesity. The Simulator of the human intestinal microbial ecosystem (SHIME) was used for studying the effect of the TCMDT diet on gut microbiota and short chain fatty acids. The TCMDT diet increased diabetes-improving microbiota (Coriobacteriaceae, Bacteroidaceae, and Peptostreptococcaceae) by 7–26 times and health-related microbiota (Rikenellaceae, Bifidobacteria, Actinobacteria) by 4–300 times. The short chain fatty acids-producers, Bacteroides and Parabacteroides were elevated after intervention. This diet significantly increased acetate (from 2.23 to 36.77 mmol/L), propionate (from 2.85 to 33.93 mmol/L), and butyrate (from 0.89 to 6.96 mmol/L), which are the major short chain fatty acids. Our study provides novel perspective into the role of gut microbiota modulation during TCMDT diet intervention. |
topic |
Whole grains Traditional Chinese medicine dietary therapy Ganoderma lucidum polysaccharides Chronic diseases intervention |
url |
http://www.sciencedirect.com/science/article/pii/S1756464619304797 |
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