Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease

Background: Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony...

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Main Authors: Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Shojiro Minomo, Yoshikazu Inoue, Katsuhiro Suzuki
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:International Journal of Mycobacteriology
Subjects:
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=76;epage=82;aulast=Kobayashi
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spelling doaj-110a69442b614bdbbb815c6dac1f6dd52020-11-25T02:01:35ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2020-01-0191768210.4103/ijmy.ijmy_14_20Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung diseaseTakehiko KobayashiKazunari TsuyuguchiShiomi YoshidaYu KuraharaShojiro MinomoYoshikazu InoueKatsuhiro SuzukiBackground: Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony morphology in MABC lung disease. Methods: This study aimed to test GPL core antigen in patients with MABC lung disease to investigate the relationship between coinfection/contamination in other nontuberculous mycobacteria species and colony morphology variant in MABC isolates. Patients with MABC lung disease and contamination diagnosed between 2012 and 2017 at our hospital were enrolled retrospectively. Results: Of the assessed patients, 43 patients with MABC lung disease and 13 with MABC contamination were included. There was a significant difference in anti-GPL-core IgA antibody levels between them (P = 0.02). Forty-three patients with MABC lung disease were divided into two groups as positive and negative antibodies groups. A significant increase in the positive anti-GPL-core IgA antibody was observed in coexistence with both Mycobacterium avium complex (MAC) (P = 0.02) and the isolate of the smooth variant (P = 0.03) in MABC.Conclusions: Anti-GPL-core IgA antibodies in patients with MABC are greatly influenced by MAC coexistence, and colony morphology variant of the MABC isolate.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=76;epage=82;aulast=Kobayashianti-glycopeptidolipid-core immunoglobulin a antibodycolony morphology variantmycobacterium avium complexmycobacteroides abscessus complex
collection DOAJ
language English
format Article
sources DOAJ
author Takehiko Kobayashi
Kazunari Tsuyuguchi
Shiomi Yoshida
Yu Kurahara
Shojiro Minomo
Yoshikazu Inoue
Katsuhiro Suzuki
spellingShingle Takehiko Kobayashi
Kazunari Tsuyuguchi
Shiomi Yoshida
Yu Kurahara
Shojiro Minomo
Yoshikazu Inoue
Katsuhiro Suzuki
Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
International Journal of Mycobacteriology
anti-glycopeptidolipid-core immunoglobulin a antibody
colony morphology variant
mycobacterium avium complex
mycobacteroides abscessus complex
author_facet Takehiko Kobayashi
Kazunari Tsuyuguchi
Shiomi Yoshida
Yu Kurahara
Shojiro Minomo
Yoshikazu Inoue
Katsuhiro Suzuki
author_sort Takehiko Kobayashi
title Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
title_short Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
title_full Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
title_fullStr Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
title_full_unstemmed Serum immunoglobulin a antibodies to glycopeptidolipid core antigen for Mycobacteroides abscessus complex lung disease
title_sort serum immunoglobulin a antibodies to glycopeptidolipid core antigen for mycobacteroides abscessus complex lung disease
publisher Wolters Kluwer Medknow Publications
series International Journal of Mycobacteriology
issn 2212-5531
2212-554X
publishDate 2020-01-01
description Background: Mycobacteroides abscessus complex (MABC) exhibits smooth morphotypes, expressing glycopeptidolipid (GPL), and rough morphotypes, expressing diminished GPL, on the MABC cell wall. Few reports have focused on the relationship between anti-GPL-core immunoglobulin A (IgA) antibody and colony morphology in MABC lung disease. Methods: This study aimed to test GPL core antigen in patients with MABC lung disease to investigate the relationship between coinfection/contamination in other nontuberculous mycobacteria species and colony morphology variant in MABC isolates. Patients with MABC lung disease and contamination diagnosed between 2012 and 2017 at our hospital were enrolled retrospectively. Results: Of the assessed patients, 43 patients with MABC lung disease and 13 with MABC contamination were included. There was a significant difference in anti-GPL-core IgA antibody levels between them (P = 0.02). Forty-three patients with MABC lung disease were divided into two groups as positive and negative antibodies groups. A significant increase in the positive anti-GPL-core IgA antibody was observed in coexistence with both Mycobacterium avium complex (MAC) (P = 0.02) and the isolate of the smooth variant (P = 0.03) in MABC.Conclusions: Anti-GPL-core IgA antibodies in patients with MABC are greatly influenced by MAC coexistence, and colony morphology variant of the MABC isolate.
topic anti-glycopeptidolipid-core immunoglobulin a antibody
colony morphology variant
mycobacterium avium complex
mycobacteroides abscessus complex
url http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=1;spage=76;epage=82;aulast=Kobayashi
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