Silencing of CCR4-NOT complex subunits affects heart structure and function

Silencing of CCR4-NOT complex subunits affects heart structure and function

The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarizati...

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Bibliographic Details
Main Authors: Lisa Elmén, Claudia B. Volpato, Anaïs Kervadec, Santiago Pineda, Sreehari Kalvakuri, Nakissa N. Alayari, Luisa Foco, Peter P. Pramstaller, Karen Ocorr, Alessandra Rossini, Anthony Cammarato, Alexandre R. Colas, Andrew A. Hicks, Rolf Bodmer
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Disease Models & Mechanisms
Subjects:
cnot1
gwas
arrhythmia
long-qt syndrome
drosophila heart
hipsc
cardiomyocytes
Online Access:http://dmm.biologists.org/content/13/7/dmm044727

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