The results of the toxicity and hazard studies of isopropyl meta-carborane with single administration to laboratory animals

• Main Authors: G. G. Yushkov, V. V. Igumenshcheva, T. M. Filippova
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2018-04-01
• Series: Acta Biomedica Scientifica
• Subjects: experiment; organic compounds of boron; isopropyl meta-carborane; toxicological studies
• Online Access: https://www.actabiomedica.ru/jour/article/view/569
• ISSN: 2541-9420; 2587-9596

Intensive research on the chemistry of borohydrides and the creation of high-energy fuels led to the discovery of a completely new type of organoboron compounds, which were collectively called carboranes. Taking into account the scope of application of organoboron compounds in various branches of human economic activity, we present for publication the quantitative data of a toxicological study of the higher isomer of carboranes of isopropyl meta-carborane at the level of a single injection into the laboratory animals through the mouth and lungs. Background. Supplementing data on toxicity and the hazard of organoboron compounds requires the study of the response of the organism to the action of isopropyl meta-carborane. The purpose of the study: identification of possible features and specificity of the toxic effect of carboranes on the example of isopropyl meta-carborane. Methods. The object of the study is nonlinear laboratory animals: rats, mice and rabbits contained in standard vivarium conditions, with observance of the rules of humane treatment of animals. Traditional methods of research (physiological, hematological, morphological) have been used. Statistical processing of data was carried out using the programs «Microsoft Office Excel 2007» and «Biostat». Differences were considered statistically significant at p < 0.05, using a parametric test. Results. Acute toxicity parameters were obtained, which allowed the substance to be classified as moderately hazardous (3rd hazard class according to GOST12.1.007), which does not have selective irritant, pneumotoxic andfibrogenic effects. Conclusion. Thus, the predominant influence of the substance is established objectively with a single exposure to the blood system as its toxicological feature, and its effect on spermatozoa is a specificity of the action, which stimulates the study of this carborane under conditions of chronic administration to the animals.