Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

• Main Authors: José Renan da Cunha-Melo, Paulo Marcos Z. Coelho
• Format: Article
• Language: English
• Published: Universidade de São Paulo 1986-08-01
• Series: Revista do Instituto de Medicina Tropical de São Paulo
• Subjects: Manson schistosomiasis; Experimental disease in mice; Antimonial drugs; Worm shift
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651986000400010&lng=en&tlng=en

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental. Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver. These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension.