Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.

Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.

The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role of NLRP3 (NALP3), its adaptor protein PYCARD (ASC), and caspase-1 during infection with Mycobacterium tuberculosis (Mtb). Mtb infection of mac...

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Bibliographic Details
Main Authors:	Erin McElvania Tekippe, Irving C Allen, Paul D Hulseberg, Jonathan T Sullivan, Jessica R McCann, Matyas Sandor, Miriam Braunstein, Jenny P-Y Ting
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-08-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2924896?pdf=render

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