The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of t...

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Main Authors: Beata Kaczmarek-Szczepańska, Olha Mazur, Marta Michalska-Sionkowska, Krzysztof Łukowicz, Anna Maria Osyczka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Materials
Subjects:
hydrogels
chitosan
glyoxal
tannic acid
cells study
Online Access:https://www.mdpi.com/1996-1944/14/9/2449
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spelling doaj-1129e9f0547e444d9fece6e7692bf08d2021-05-31T23:30:38ZengMDPI AGMaterials1996-19442021-05-01142449244910.3390/ma14092449The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by GlyoxalBeata Kaczmarek-Szczepańska0Olha Mazur1Marta Michalska-Sionkowska2Krzysztof Łukowicz3Anna Maria Osyczka4Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Toruń, PolandDepartment of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Toruń, PolandDepartment of Environmental Microbiology and Biotechnology, Faculty of Biology and Veterinary Science, Nicolaus Copernicus University in Toruń, Lwowska 1, 87-100 Toruń, PolandDepartment of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandDepartment of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandIn this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.https://www.mdpi.com/1996-1944/14/9/2449hydrogelschitosanglyoxaltannic acidcells study
collection DOAJ
language English
format Article
sources DOAJ
author Beata Kaczmarek-Szczepańska
Olha Mazur
Marta Michalska-Sionkowska
Krzysztof Łukowicz
Anna Maria Osyczka
spellingShingle Beata Kaczmarek-Szczepańska
Olha Mazur
Marta Michalska-Sionkowska
Krzysztof Łukowicz
Anna Maria Osyczka
The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
Materials
hydrogels
chitosan
glyoxal
tannic acid
cells study
author_facet Beata Kaczmarek-Szczepańska
Olha Mazur
Marta Michalska-Sionkowska
Krzysztof Łukowicz
Anna Maria Osyczka
author_sort Beata Kaczmarek-Szczepańska
title The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
title_short The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
title_full The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
title_fullStr The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
title_full_unstemmed The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal
title_sort preparation and characterization of chitosan-based hydrogels cross-linked by glyoxal
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2021-05-01
description In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.
topic hydrogels
chitosan
glyoxal
tannic acid
cells study
url https://www.mdpi.com/1996-1944/14/9/2449
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