Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/3/429 |
| id |
doaj-112ab41f0e1d48e4865d87e8e76958c8 |
|---|---|
| record_format |
Article |
| spelling |
doaj-112ab41f0e1d48e4865d87e8e76958c82020-11-25T01:29:14ZengMDPI AGMolecules1420-30492019-01-0124342910.3390/molecules24030429molecules24030429Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer TherapySefan Asamitsu0Shunsuke Obata1Zutao Yu2Toshikazu Bando3Hiroshi Sugiyama4Department of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, JapanDepartment of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, JapanDepartment of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, JapanDepartment of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, JapanDepartment of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, JapanA G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.https://www.mdpi.com/1420-3049/24/3/429cancer therapytelomereoncogenesG-quadruplexselective ligands |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sefan Asamitsu Shunsuke Obata Zutao Yu Toshikazu Bando Hiroshi Sugiyama |
| spellingShingle |
Sefan Asamitsu Shunsuke Obata Zutao Yu Toshikazu Bando Hiroshi Sugiyama Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy Molecules cancer therapy telomere oncogenes G-quadruplex selective ligands |
| author_facet |
Sefan Asamitsu Shunsuke Obata Zutao Yu Toshikazu Bando Hiroshi Sugiyama |
| author_sort |
Sefan Asamitsu |
| title |
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy |
| title_short |
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy |
| title_full |
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy |
| title_fullStr |
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy |
| title_full_unstemmed |
Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy |
| title_sort |
recent progress of targeted g-quadruplex-preferred ligands toward cancer therapy |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2019-01-01 |
| description |
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs. |
| topic |
cancer therapy telomere oncogenes G-quadruplex selective ligands |
| url |
https://www.mdpi.com/1420-3049/24/3/429 |
| work_keys_str_mv |
AT sefanasamitsu recentprogressoftargetedgquadruplexpreferredligandstowardcancertherapy AT shunsukeobata recentprogressoftargetedgquadruplexpreferredligandstowardcancertherapy AT zutaoyu recentprogressoftargetedgquadruplexpreferredligandstowardcancertherapy AT toshikazubando recentprogressoftargetedgquadruplexpreferredligandstowardcancertherapy AT hiroshisugiyama recentprogressoftargetedgquadruplexpreferredligandstowardcancertherapy |
| _version_ |
1725097660342337536 |