Association between periodontal pathogens and systemic disease

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adv...

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Main Authors:	Fiona Q. Bui, Cassio Luiz Coutinho Almeida-da-Silva, Brandon Huynh, Alston Trinh, Jessica Liu, Jacob Woodward, Homer Asadi, David M. Ojcius
Format:	Article
Language:	English
Published:	Elsevier 2019-02-01
Series:	Biomedical Journal
Online Access:	http://www.sciencedirect.com/science/article/pii/S2319417018302634

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spelling	doaj-112b5ecdc3d646599dd8960d9ad32c3e2021-02-02T05:34:43ZengElsevierBiomedical Journal2319-41702019-02-014212735Association between periodontal pathogens and systemic diseaseFiona Q. Bui0Cassio Luiz Coutinho Almeida-da-Silva1Brandon Huynh2Alston Trinh3Jessica Liu4Jacob Woodward5Homer Asadi6David M. Ojcius7Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA; Immunobiology Program, Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilDepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USADepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA; Corresponding author. Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, 155 Fifth Street, San Francisco, CA 94103, USA.A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease. Keywords: Oral pathogens, Systemic disease, Periodontal disease, Chronic disease, Inflammation, Dentistryhttp://www.sciencedirect.com/science/article/pii/S2319417018302634
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fiona Q. Bui Cassio Luiz Coutinho Almeida-da-Silva Brandon Huynh Alston Trinh Jessica Liu Jacob Woodward Homer Asadi David M. Ojcius
spellingShingle	Fiona Q. Bui Cassio Luiz Coutinho Almeida-da-Silva Brandon Huynh Alston Trinh Jessica Liu Jacob Woodward Homer Asadi David M. Ojcius Association between periodontal pathogens and systemic disease Biomedical Journal
author_facet	Fiona Q. Bui Cassio Luiz Coutinho Almeida-da-Silva Brandon Huynh Alston Trinh Jessica Liu Jacob Woodward Homer Asadi David M. Ojcius
author_sort	Fiona Q. Bui
title	Association between periodontal pathogens and systemic disease
title_short	Association between periodontal pathogens and systemic disease
title_full	Association between periodontal pathogens and systemic disease
title_fullStr	Association between periodontal pathogens and systemic disease
title_full_unstemmed	Association between periodontal pathogens and systemic disease
title_sort	association between periodontal pathogens and systemic disease
publisher	Elsevier
series	Biomedical Journal
issn	2319-4170
publishDate	2019-02-01
description	A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease. Keywords: Oral pathogens, Systemic disease, Periodontal disease, Chronic disease, Inflammation, Dentistry
url	http://www.sciencedirect.com/science/article/pii/S2319417018302634
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Association between periodontal pathogens and systemic disease

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