Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis

Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis (JIA) is characterized by a loss of immune tolerance. Here, the balance between the activity of effector T (Teff) cells and regulatory T (Treg) cells is disturbed resulting in chronic inflammation in the joints. Presently, therapeutic strategies are predominantly aimed...

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Bibliographic Details
Main Authors: Lotte Nijhuis, Janneke G. C. Peeters, Sebastiaan J. Vastert, Jorg van Loosdregt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
juvenile idiopathic arthritis (JIA)
acetylation
HDAC inhibitor (histone deacetylase inhibitor)
T cells
tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00151/full

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