The Role of Extracellular Vesicles in Bone Metastasis
Multiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. Despite being the focus of intense investigation, the molecular and cellular mechanisms that regulate the metastasis of disseminated tumor cells still remain largely unknown. Bone me...
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doaj-113af3dac176441fbb8139d19aac8e5b2020-11-24T21:52:10ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-04-01194113610.3390/ijms19041136ijms19041136The Role of Extracellular Vesicles in Bone MetastasisMichela Rossi0Giulia Battafarano1Matteo D’Agostini2Andrea Del Fattore3Bone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyBone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyClinical Laboratory, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyBone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyMultiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. Despite being the focus of intense investigation, the molecular and cellular mechanisms that regulate the metastasis of disseminated tumor cells still remain largely unknown. Bone metastases severely impact quality of life since they are associated with pain, fractures, and bone marrow aplasia. In this review, we will summarize the recent discoveries on the role of extracellular vesicles (EV) in the regulation of bone remodeling activity and bone metastasis occurrence. Indeed, it was shown that extracellular vesicles, including exosomes and microvesicles, released from tumor cells can modify the bone microenvironment, allowing the formation of osteolytic, osteosclerotic, and mixed mestastases. In turn, bone-derived EV can stimulate the proliferation of tumor cells. The inhibition of EV-mediated crosstalk between cancer and bone cells could represent a new therapeutic target for bone metastasis.http://www.mdpi.com/1422-0067/19/4/1136bone metastasisextracellular vesiclesexosomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michela Rossi Giulia Battafarano Matteo D’Agostini Andrea Del Fattore |
spellingShingle |
Michela Rossi Giulia Battafarano Matteo D’Agostini Andrea Del Fattore The Role of Extracellular Vesicles in Bone Metastasis International Journal of Molecular Sciences bone metastasis extracellular vesicles exosomes |
author_facet |
Michela Rossi Giulia Battafarano Matteo D’Agostini Andrea Del Fattore |
author_sort |
Michela Rossi |
title |
The Role of Extracellular Vesicles in Bone Metastasis |
title_short |
The Role of Extracellular Vesicles in Bone Metastasis |
title_full |
The Role of Extracellular Vesicles in Bone Metastasis |
title_fullStr |
The Role of Extracellular Vesicles in Bone Metastasis |
title_full_unstemmed |
The Role of Extracellular Vesicles in Bone Metastasis |
title_sort |
role of extracellular vesicles in bone metastasis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-04-01 |
description |
Multiple types of cancer have the specific ability to home to the bone microenvironment and cause metastatic lesions. Despite being the focus of intense investigation, the molecular and cellular mechanisms that regulate the metastasis of disseminated tumor cells still remain largely unknown. Bone metastases severely impact quality of life since they are associated with pain, fractures, and bone marrow aplasia. In this review, we will summarize the recent discoveries on the role of extracellular vesicles (EV) in the regulation of bone remodeling activity and bone metastasis occurrence. Indeed, it was shown that extracellular vesicles, including exosomes and microvesicles, released from tumor cells can modify the bone microenvironment, allowing the formation of osteolytic, osteosclerotic, and mixed mestastases. In turn, bone-derived EV can stimulate the proliferation of tumor cells. The inhibition of EV-mediated crosstalk between cancer and bone cells could represent a new therapeutic target for bone metastasis. |
topic |
bone metastasis extracellular vesicles exosomes |
url |
http://www.mdpi.com/1422-0067/19/4/1136 |
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