CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

Abstract Background Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause abnormal enlargement of alveoli and lead to bronchopulmonary dysplasia (B...

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Bibliographic Details
Main Authors: Yen-Ting Lai, Hsu-Wen Chao, Alan Chuan-Ying Lai, Shu-Hui Lin, Ya-Jen Chang, Yi-Shuian Huang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Biomedical Science
Subjects:
Alveologenesis, Bronchopulmonary dysplasia
CPEB2
Myofibroblast
PDGFRα
Translational control
Online Access:http://link.springer.com/article/10.1186/s12929-020-00643-0

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