Ketoconazole in the treatment of cryptococcosis of the central nervous system

Ketoconazole in the treatment of cryptococcosis of the central nervous system

Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day...

Full description

Bibliographic Details
Main Authors: P. C. Trevisol-Bittencourt, J. W. A. S. Sander, C. S. Silvado, E. O. Wittig
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 1991-06-01
Series:Arquivos de Neuro-Psiquiatria
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016&lng=en&tlng=en
id doaj-1144e6f44d464e7296aed99046147b3e
record_format Article
spelling doaj-1144e6f44d464e7296aed99046147b3e2020-11-24T23:17:17ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271991-06-0149220821010.1590/S0004-282X1991000200016S0004-282X1991000200016Ketoconazole in the treatment of cryptococcosis of the central nervous systemP. C. Trevisol-Bittencourt0J. W. A. S. Sander1C. S. Silvado2E. O. Wittig3Universidade Federal de Santa CatarinaUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáTwo patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016&lng=en&tlng=en
collection DOAJ
language English
format Article
sources DOAJ
author P. C. Trevisol-Bittencourt
J. W. A. S. Sander
C. S. Silvado
E. O. Wittig
spellingShingle P. C. Trevisol-Bittencourt
J. W. A. S. Sander
C. S. Silvado
E. O. Wittig
Ketoconazole in the treatment of cryptococcosis of the central nervous system
Arquivos de Neuro-Psiquiatria
author_facet P. C. Trevisol-Bittencourt
J. W. A. S. Sander
C. S. Silvado
E. O. Wittig
author_sort P. C. Trevisol-Bittencourt
title Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_short Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_full Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_fullStr Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_full_unstemmed Ketoconazole in the treatment of cryptococcosis of the central nervous system
title_sort ketoconazole in the treatment of cryptococcosis of the central nervous system
publisher Academia Brasileira de Neurologia (ABNEURO)
series Arquivos de Neuro-Psiquiatria
issn 1678-4227
publishDate 1991-06-01
description Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties; they had either failed standard therapy (Amphotericin-B + 5-Flurocytosine) or suffred intolerable side-effects to it. Both patients were administered KTZ 800 mg/day as monotherapy for six months without interruption and both responded. One month after KTZ therapy was withdrawn, however, a relapse of the infection was seen in one case. Side-effects were minimal during the trial of treatment. KTZ could be a useful drug in some cases of neurocryptococcosis.
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1991000200016&lng=en&tlng=en
work_keys_str_mv AT pctrevisolbittencourt ketoconazoleinthetreatmentofcryptococcosisofthecentralnervoussystem
AT jwassander ketoconazoleinthetreatmentofcryptococcosisofthecentralnervoussystem
AT cssilvado ketoconazoleinthetreatmentofcryptococcosisofthecentralnervoussystem
AT eowittig ketoconazoleinthetreatmentofcryptococcosisofthecentralnervoussystem
_version_ 1725583834162921472

Similar Items