Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21517-5 |
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doaj-1150a301edaa40a0aaee3f7007324f2a2021-02-23T10:35:12ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21517-5Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primatesZongliang Chang0Weibing Qin1Huili Zheng2Kathleen Schegg3Lu Han4Xiaohua Liu5Yue Wang6Zhuqing Wang7Hayden McSwiggin8Hongying Peng9Shuiqiao Yuan10Jiabao Wu11Yongxia Wang12Shenghui Zhu13Yanjia Jiang14Hua Nie15Yuan Tang16Yu Zhou17Michael J. M. Hitchcock18Yunge Tang19Wei Yan20Department of Physiology and Cell Biology, University of Nevada, Reno School of MedicineNHC Key Laboratory of Male Reproduction and GeneticsDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsNHC Key Laboratory of Male Reproduction and GeneticsDepartment of Microbiology and Immunology, University of Nevada, Reno School of MedicineNHC Key Laboratory of Male Reproduction and GeneticsDepartment of Physiology and Cell Biology, University of Nevada, Reno School of MedicineNo male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.https://doi.org/10.1038/s41467-021-21517-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zongliang Chang Weibing Qin Huili Zheng Kathleen Schegg Lu Han Xiaohua Liu Yue Wang Zhuqing Wang Hayden McSwiggin Hongying Peng Shuiqiao Yuan Jiabao Wu Yongxia Wang Shenghui Zhu Yanjia Jiang Hua Nie Yuan Tang Yu Zhou Michael J. M. Hitchcock Yunge Tang Wei Yan |
| spellingShingle |
Zongliang Chang Weibing Qin Huili Zheng Kathleen Schegg Lu Han Xiaohua Liu Yue Wang Zhuqing Wang Hayden McSwiggin Hongying Peng Shuiqiao Yuan Jiabao Wu Yongxia Wang Shenghui Zhu Yanjia Jiang Hua Nie Yuan Tang Yu Zhou Michael J. M. Hitchcock Yunge Tang Wei Yan Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates Nature Communications |
| author_facet |
Zongliang Chang Weibing Qin Huili Zheng Kathleen Schegg Lu Han Xiaohua Liu Yue Wang Zhuqing Wang Hayden McSwiggin Hongying Peng Shuiqiao Yuan Jiabao Wu Yongxia Wang Shenghui Zhu Yanjia Jiang Hua Nie Yuan Tang Yu Zhou Michael J. M. Hitchcock Yunge Tang Wei Yan |
| author_sort |
Zongliang Chang |
| title |
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| title_short |
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| title_full |
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| title_fullStr |
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| title_full_unstemmed |
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| title_sort |
triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-02-01 |
| description |
No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys. |
| url |
https://doi.org/10.1038/s41467-021-21517-5 |
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