Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.
Main Authors: | Zongliang Chang, Weibing Qin, Huili Zheng, Kathleen Schegg, Lu Han, Xiaohua Liu, Yue Wang, Zhuqing Wang, Hayden McSwiggin, Hongying Peng, Shuiqiao Yuan, Jiabao Wu, Yongxia Wang, Shenghui Zhu, Yanjia Jiang, Hua Nie, Yuan Tang, Yu Zhou, Michael J. M. Hitchcock, Yunge Tang, Wei Yan |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21517-5 |
Similar Items
-
Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.
by: Daniel Oliver, et al.
Published: (2015-01-01) -
Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype
by: Zhuqing Wang, et al.
Published: (2019-05-01) -
Identification of a cellular target of triptonide and its functional study
by: Zhou, Yiqing, et al.
Published: (2013) -
Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment
by: Bowen Gao, et al.
Published: (2021-01-01) -
Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice
by: Jin Zhang, et al.
Published: (2019-11-01)