Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study
Introduction: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation. Methods: A new Dose Limiting Toxicity definition was used. The concept of Target Ceiling Dose was...
Main Authors: | Jacques Medioni, Mara Brizard, Reza Elaidi, Paul F. Reid, Khadija Benlhassan, Dorothy Bray |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-09-01
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Series: | Contemporary Clinical Trials Communications |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865416301053 |
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