Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics
The evaluation of coronary lesions has evolved in recent years. Physiologic-guided revascularization (particularly with pressure-derived fractional flow reserve (FFR)) has led to superior outcomes compared to traditional angiographic assessment. A greater importance, therefore, has been placed on th...
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doaj-1158cd0a3b7740df990ad0d9a38c89d62020-11-24T21:53:48ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019366510.3390/jcm9030665jcm9030665Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque CharacteristicsJohn-Ross D. Clarke0Freddy Duarte Lau1Stuart W. Zarich2Department of Internal Medicine, Yale-New Haven Health/Bridgeport Hospital, Bridgeport, CT 06610, USADepartment of Internal Medicine, Yale-New Haven Health/Bridgeport Hospital, Bridgeport, CT 06610, USAThe Heart and Vascular Institute, Yale-New Haven Health/Bridgeport Hospital, Bridgeport, CT 06610, USAThe evaluation of coronary lesions has evolved in recent years. Physiologic-guided revascularization (particularly with pressure-derived fractional flow reserve (FFR)) has led to superior outcomes compared to traditional angiographic assessment. A greater importance, therefore, has been placed on the functional significance of an epicardial lesion. Despite the improvements in the limitations of angiography, insights into the relationship between hemodynamic significance and plaque morphology at the lesion level has shown that determining the implications of epicardial lesions is rather complex. Investigators have sought greater understanding by correlating ischemia quantified by FFR with plaque characteristics determined on invasive and non-invasive modalities. We review the background of the use of these diagnostic tools in coronary artery disease and discuss the implications of analyzing physiological stenosis severity and plaque characteristics concurrently.https://www.mdpi.com/2077-0383/9/3/665fractional flow reservecoronary artery diseaseatherosclerosisplaque characteristics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John-Ross D. Clarke Freddy Duarte Lau Stuart W. Zarich |
spellingShingle |
John-Ross D. Clarke Freddy Duarte Lau Stuart W. Zarich Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics Journal of Clinical Medicine fractional flow reserve coronary artery disease atherosclerosis plaque characteristics |
author_facet |
John-Ross D. Clarke Freddy Duarte Lau Stuart W. Zarich |
author_sort |
John-Ross D. Clarke |
title |
Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics |
title_short |
Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics |
title_full |
Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics |
title_fullStr |
Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics |
title_full_unstemmed |
Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics |
title_sort |
determining the significance of coronary plaque lesions: physiological stenosis severity and plaque characteristics |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
The evaluation of coronary lesions has evolved in recent years. Physiologic-guided revascularization (particularly with pressure-derived fractional flow reserve (FFR)) has led to superior outcomes compared to traditional angiographic assessment. A greater importance, therefore, has been placed on the functional significance of an epicardial lesion. Despite the improvements in the limitations of angiography, insights into the relationship between hemodynamic significance and plaque morphology at the lesion level has shown that determining the implications of epicardial lesions is rather complex. Investigators have sought greater understanding by correlating ischemia quantified by FFR with plaque characteristics determined on invasive and non-invasive modalities. We review the background of the use of these diagnostic tools in coronary artery disease and discuss the implications of analyzing physiological stenosis severity and plaque characteristics concurrently. |
topic |
fractional flow reserve coronary artery disease atherosclerosis plaque characteristics |
url |
https://www.mdpi.com/2077-0383/9/3/665 |
work_keys_str_mv |
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