Single endemic genotype of measles virus continuously circulating in China for at least 16 years.
The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles case...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3332093?pdf=render |
id |
doaj-115b3b5256e84959aa489221bbb019ed |
---|---|
record_format |
Article |
spelling |
doaj-115b3b5256e84959aa489221bbb019ed2020-11-25T02:16:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3440110.1371/journal.pone.0034401Single endemic genotype of measles virus continuously circulating in China for at least 16 years.Yan ZhangSongtao XuHuiling WangZhen ZhuYixin JiChunyu LiuXiaojie ZhangLiwei SunJianhui ZhouPeishan LuYing HuDaxing FengZhenying ZhangChangyin WangXueqiang FangHuanying ZhengLeng LiuXiaodong SunWei TangYan WangYan LiuHui GaoHong TianJiangtao MaSuyi GuShuang WangYan FengFang BoJianfeng LiuYuan SiShujie ZhouYuyan MaShengwei WuShunde ZhouFangcai LiZhengrong DingZhaohui YangPaul A RotaDavid FeatherstoneYoungmee JeeWilliam J BelliniWenbo XuThe incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%-100% and 84.7%-100%, H1b were 97.1%-100% and 95.3%-100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years.http://europepmc.org/articles/PMC3332093?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Zhang Songtao Xu Huiling Wang Zhen Zhu Yixin Ji Chunyu Liu Xiaojie Zhang Liwei Sun Jianhui Zhou Peishan Lu Ying Hu Daxing Feng Zhenying Zhang Changyin Wang Xueqiang Fang Huanying Zheng Leng Liu Xiaodong Sun Wei Tang Yan Wang Yan Liu Hui Gao Hong Tian Jiangtao Ma Suyi Gu Shuang Wang Yan Feng Fang Bo Jianfeng Liu Yuan Si Shujie Zhou Yuyan Ma Shengwei Wu Shunde Zhou Fangcai Li Zhengrong Ding Zhaohui Yang Paul A Rota David Featherstone Youngmee Jee William J Bellini Wenbo Xu |
spellingShingle |
Yan Zhang Songtao Xu Huiling Wang Zhen Zhu Yixin Ji Chunyu Liu Xiaojie Zhang Liwei Sun Jianhui Zhou Peishan Lu Ying Hu Daxing Feng Zhenying Zhang Changyin Wang Xueqiang Fang Huanying Zheng Leng Liu Xiaodong Sun Wei Tang Yan Wang Yan Liu Hui Gao Hong Tian Jiangtao Ma Suyi Gu Shuang Wang Yan Feng Fang Bo Jianfeng Liu Yuan Si Shujie Zhou Yuyan Ma Shengwei Wu Shunde Zhou Fangcai Li Zhengrong Ding Zhaohui Yang Paul A Rota David Featherstone Youngmee Jee William J Bellini Wenbo Xu Single endemic genotype of measles virus continuously circulating in China for at least 16 years. PLoS ONE |
author_facet |
Yan Zhang Songtao Xu Huiling Wang Zhen Zhu Yixin Ji Chunyu Liu Xiaojie Zhang Liwei Sun Jianhui Zhou Peishan Lu Ying Hu Daxing Feng Zhenying Zhang Changyin Wang Xueqiang Fang Huanying Zheng Leng Liu Xiaodong Sun Wei Tang Yan Wang Yan Liu Hui Gao Hong Tian Jiangtao Ma Suyi Gu Shuang Wang Yan Feng Fang Bo Jianfeng Liu Yuan Si Shujie Zhou Yuyan Ma Shengwei Wu Shunde Zhou Fangcai Li Zhengrong Ding Zhaohui Yang Paul A Rota David Featherstone Youngmee Jee William J Bellini Wenbo Xu |
author_sort |
Yan Zhang |
title |
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. |
title_short |
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. |
title_full |
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. |
title_fullStr |
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. |
title_full_unstemmed |
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. |
title_sort |
single endemic genotype of measles virus continuously circulating in china for at least 16 years. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%-100% and 84.7%-100%, H1b were 97.1%-100% and 95.3%-100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years. |
url |
http://europepmc.org/articles/PMC3332093?pdf=render |
work_keys_str_mv |
AT yanzhang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT songtaoxu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT huilingwang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT zhenzhu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yixinji singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT chunyuliu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT xiaojiezhang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT liweisun singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT jianhuizhou singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT peishanlu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yinghu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT daxingfeng singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT zhenyingzhang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT changyinwang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT xueqiangfang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT huanyingzheng singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT lengliu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT xiaodongsun singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT weitang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yanwang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yanliu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT huigao singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT hongtian singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT jiangtaoma singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT suyigu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT shuangwang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yanfeng singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT fangbo singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT jianfengliu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yuansi singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT shujiezhou singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT yuyanma singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT shengweiwu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT shundezhou singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT fangcaili singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT zhengrongding singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT zhaohuiyang singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT paularota singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT davidfeatherstone singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT youngmeejee singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT williamjbellini singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years AT wenboxu singleendemicgenotypeofmeaslesviruscontinuouslycirculatinginchinaforatleast16years |
_version_ |
1724893508993548288 |