Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice

Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice

Prion disease is a group of transmissible neurodegenerative disorders affecting humans and animals. The prion hypothesis postulates that PrP<sup>Sc</sup>, the pathogenic conformer of host-encoded prion protein (PrP), is the unconventional proteinaceous infectious agent called prion. Supp...

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Bibliographic Details
Main Authors: Chenhua Pan, Junwei Yang, Xiangyi Zhang, Ying Chen, Shunxiong Wei, Guohua Yu, Yi-Hsuan Pan, Jiyan Ma, Chonggang Yuan
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pathogens
Subjects:
prion
recPrP<sup>Sc</sup>
oral transmission
prion disease
Online Access:https://www.mdpi.com/2076-0817/9/8/653

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