MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION?
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which both focal demyelinating lesions and diffuse axonal loss are present. The relationship between the inflammatory/ demyelinating process and the neurodegenerative component of the disease are extrem...
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doaj-116d90c340cf4302b6c03a62751de7872020-11-25T02:49:22ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942007-06-0162636610.37897/RJN.2007.2.1MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION?O. Bajenaru0University of Medicine and Pharmacy „Carol Davila“ Bucharest; University Hospital of Emergency Bucharest, Department of NeurologyMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which both focal demyelinating lesions and diffuse axonal loss are present. The relationship between the inflammatory/ demyelinating process and the neurodegenerative component of the disease are extremely complex and not yet fully understood, but recent data show that their coexistence is present very early during the evolution, even in the preclinical stages of the disease. There are also extremely important clinical correlations between the focal inflammatory/ demyelinating lesions and the potential reversible clinical relapses and between the permanent axonal loss and continuous neurodegenerative process (extended also beyond the focal lesions in the normal appearing white matter and gray matter) and the irreversible brain and spinal cord atrophy which are irreversible and is the cause of clinical invalidity, mainly in the progressive forms of disease. MS is a heterogenous disease and there are now described four pathophysiologic patterns which are also correlated with the clinical heterogenity. Many factors, including genetic and environmental conditions, are responsible for this heterogeneicity, influencing the extremly complex pathogenic pathways. Recent data put into evidence details concerning the mechanisms of the neurodegenerative pathways in MS, which could be the background for future neuroprotective therapeutic strategies which could have, in association with the immunomodulatory treatments (now available in clinical practice) the potential capacity to slow-down or even to stop the clinical deterioration of these patients. These potential therapeutic strategies are reviwed in the final discussion.https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2007-Nr.2/RJN_2007_2_Art-01.pdfchronic inflammatory diseasedisease heterogeneicitypathophysiological patternsfocal demyelinationdiffuse axonal lossnormal appearing white matter (nawm)brain and spinal cord atrophyneuroprotection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
O. Bajenaru |
spellingShingle |
O. Bajenaru MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? Romanian Journal of Neurology chronic inflammatory disease disease heterogeneicity pathophysiological patterns focal demyelination diffuse axonal loss normal appearing white matter (nawm) brain and spinal cord atrophy neuroprotection |
author_facet |
O. Bajenaru |
author_sort |
O. Bajenaru |
title |
MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? |
title_short |
MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? |
title_full |
MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? |
title_fullStr |
MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? |
title_full_unstemmed |
MECHANISMS OF NEURODEGENERATION IN MULTIPLE SCLEROSIS: PREMISE FOR NEUROPROTECTION? |
title_sort |
mechanisms of neurodegeneration in multiple sclerosis: premise for neuroprotection? |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Neurology |
issn |
1843-8148 2069-6094 |
publishDate |
2007-06-01 |
description |
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which both focal demyelinating lesions and diffuse axonal loss are present. The relationship between the inflammatory/ demyelinating process and the neurodegenerative component of the disease are extremely complex and not yet fully understood, but recent data show that their coexistence is present very early during the evolution, even in the preclinical stages of the disease. There are also extremely important clinical correlations between the focal inflammatory/ demyelinating lesions and the potential reversible clinical relapses and between the permanent axonal loss and continuous neurodegenerative process (extended also beyond the focal lesions in the normal appearing white matter and gray matter) and the irreversible brain and spinal cord atrophy which are irreversible and is the cause of clinical invalidity, mainly in the progressive forms of disease. MS is a heterogenous disease and there are now described four pathophysiologic patterns which are also correlated with the clinical heterogenity. Many factors, including genetic and environmental conditions, are responsible for this heterogeneicity, influencing the extremly complex pathogenic pathways. Recent data put into evidence details concerning the mechanisms of the neurodegenerative pathways in MS, which could be the background for future neuroprotective therapeutic strategies which could have, in association with the immunomodulatory treatments (now available in clinical practice) the potential capacity to slow-down or even to stop the clinical deterioration of these patients. These potential therapeutic strategies are reviwed in the final discussion. |
topic |
chronic inflammatory disease disease heterogeneicity pathophysiological patterns focal demyelination diffuse axonal loss normal appearing white matter (nawm) brain and spinal cord atrophy neuroprotection |
url |
https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2007-Nr.2/RJN_2007_2_Art-01.pdf |
work_keys_str_mv |
AT obajenaru mechanismsofneurodegenerationinmultiplesclerosispremiseforneuroprotection |
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1724743832939003904 |