Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.

Bibliographic Details
Main Authors: Yun Zhao, Rachid Zagani, Sung-Moo Park, Naohiro Yoshida, Pankaj Shah, Hans-Christian Reinecker
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09283-x
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spelling doaj-116dd64c0f8148448455c70c181f4b022021-05-11T12:12:26ZengNature Publishing GroupNature Communications2041-17232019-03-0110111310.1038/s41467-019-09283-xMicrobial recognition by GEF-H1 controls IKKε mediated activation of IRF5Yun Zhao0Rachid Zagani1Sung-Moo Park2Naohiro Yoshida3Pankaj Shah4Hans-Christian Reinecker5Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical SchoolThe transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.https://doi.org/10.1038/s41467-019-09283-x
collection DOAJ
language English
format Article
sources DOAJ
author Yun Zhao
Rachid Zagani
Sung-Moo Park
Naohiro Yoshida
Pankaj Shah
Hans-Christian Reinecker
spellingShingle Yun Zhao
Rachid Zagani
Sung-Moo Park
Naohiro Yoshida
Pankaj Shah
Hans-Christian Reinecker
Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
Nature Communications
author_facet Yun Zhao
Rachid Zagani
Sung-Moo Park
Naohiro Yoshida
Pankaj Shah
Hans-Christian Reinecker
author_sort Yun Zhao
title Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_short Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_full Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_fullStr Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_full_unstemmed Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_sort microbial recognition by gef-h1 controls ikkε mediated activation of irf5
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.
url https://doi.org/10.1038/s41467-019-09283-x
work_keys_str_mv AT yunzhao microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
AT rachidzagani microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
AT sungmoopark microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
AT naohiroyoshida microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
AT pankajshah microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
AT hanschristianreinecker microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
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