AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual d...
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Bibliographic Details
| Main Authors: |
Aline Brechet,
Rebecca Buchert,
Jochen Schwenk,
Sami Boudkkazi,
Gerd Zolles,
Karine Siquier-Pernet,
Irene Schaber,
Wolfgang Bildl,
Abdelkrim Saadi,
Christine Bole-Feysot,
Patrick Nitschke,
Andre Reis,
Heinrich Sticht,
Nouriya Al-Sanna’a,
Arndt Rolfs,
Akos Kulik,
Uwe Schulte,
Laurence Colleaux,
Rami Abou Jamra,
Bernd Fakler |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15910
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