| Summary: | Chemotherapy affect skin and its appendages. Nail changes due to chemotherapeutic agents are common asymptomatic and usually resolve after discontinuation of therapy. There are various chemotherapeutic agents implicated for the changes like vincristine, hydroxyurea, etoposide, daunorubicin, bleomycin, cyclophosphamide etc. We report a case undergoing chemotherapy with etoposide and cyclophosphamide who had beau’s and Mee’s line simultaneously. Clinical acumen including history taking, knowledge about chemotherapy induced nail changes, counselling of the patient are prerequisite to diagnose such cases deferring unnecessary diagnostic workup and treatment.
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